Home
Clinical Trials
Lupus Genetics Studies

Lupus Genetics Studies

Last Updated: 2017-09-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

3460 participants

Study Classification

OBSERVATIONAL

Study Start Date

1995-10-31

Study Completion Date

2013-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Lupus Genetics Studies and Lupus Family Registry \& Repository are working to find the genes that reveal the causes of systemic lupus erythematosus (SLE, or lupus). The study is enrolling families of all ethnic backgrounds from the United States, Canada, Puerto Rico, and the Virgin Islands that have one or more living members diagnosed with SLE.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

SLE is an often crippling and potentially fatal autoimmune disease that is nine times more prevalent in women than in men, and four times more likely to affect African American females than Caucasian females. It is suspected that a genetic predisposition along with environmental factors contribute to the clinical manifestation of SLE. The Lupus Genetics Studies consist of several familial SLE studies, including the Lupus Family Registry \& Repository (LFRR, formerly known as the Lupus Multiplex Registry \& Repository, or LMRR). The Lupus Studies enroll families of all ethnicities with one or more members diagnosed with systemic lupus to determine what genes contribute to the development of the disease.

Additionally, the Lupus Family Registry \& Repository is the largest repository of its kind in North America. In addition to the research done on site, the Repository serves as a national resource for scientists interested in conducting research on SLE and families either simplex or multiplex for lupus. Data, serum samples, and DNA samples are available to researchers. By collecting families in which two or more living individuals have been diagnosed with SLE, the study is utilizing the genetic link between the affected family members to discover disease-associated genes.

Records will be requested from the patients' treating physicians to document various lupus symptoms and related problems. One-time blood samples will be collected from the patients as well as from certain family members and an unrelated volunteer. There is no cost to participate and the study pays for sample draws and shipping.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Systemic Lupus Erythematosus

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

FAMILY_BASED

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Families in which one or more living members have been diagnosed with systemic lupus erythematosus

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

John B. Harley, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Member & Program Head, Arthritis and Immunology Research Program; Oklahoma Medical Research Foundation

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Oklahoma Medical Research Foundation

Oklahoma City, Oklahoma, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB. The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis. Rheumatology (Oxford). 2007 Jan;46(1):49-56. doi: 10.1093/rheumatology/kel170. Epub 2006 Jun 7.

Reference Type BACKGROUND

PMID: 16760194 (View on PubMed)

Xing C, Sestak AL, Kelly JA, Nguyen KL, Bruner GR, Harley JB, Gray-McGuire C. Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet. 2007 Jan;120(5):623-31. doi: 10.1007/s00439-006-0248-4. Epub 2006 Sep 16.

Reference Type BACKGROUND

PMID: 16983533 (View on PubMed)

Harley JB, Kelly JA, Kaufman KM. Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol. 2006 Oct;28(2):119-30. doi: 10.1007/s00281-006-0040-5. Epub 2006 Sep 22.

Reference Type BACKGROUND

PMID: 17021721 (View on PubMed)

Forabosco P, Gorman JD, Cleveland C, Kelly JA, Fisher SA, Ortmann WA, Johansson C, Johanneson B, Moser KL, Gaffney PM, Tsao BP, Cantor RM, Alarcon-Riquelme ME, Behrens TW, Harley JB, Lewis CM, Criswell LA. Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. Genes Immun. 2006 Oct;7(7):609-14. doi: 10.1038/sj.gene.6364338. Epub 2006 Sep 14.

Reference Type BACKGROUND

PMID: 16971955 (View on PubMed)

Scofield RH, Bruner GR, Harley JB, Namjou B. Autoimmune thyroid disease is associated with a diagnosis of secondary Sjogren's syndrome in familial systemic lupus. Ann Rheum Dis. 2007 Mar;66(3):410-3. doi: 10.1136/ard.2006.055103. Epub 2006 Sep 19.

Reference Type BACKGROUND

PMID: 16984944 (View on PubMed)

Kaufman KM, Kelly JA, Herring BJ, Adler AJ, Glenn SB, Namjou B, Frank SG, Dawson SL, Bruner GR, James JA, Harley JB. Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum. 2006 Aug;54(8):2533-40. doi: 10.1002/art.21963.

Reference Type BACKGROUND

PMID: 16868974 (View on PubMed)

Ramos PS, Kelly JA, Gray-McGuire C, Bruner GR, Leiran AN, Meyer CM, Namjou B, Espe KJ, Ortmann WA, Reichlin M, Langefeld CD, James JA, Gaffney PM, Behrens TW, Harley JB, Moser KL. Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus. Genes Immun. 2006 Jul;7(5):417-32. doi: 10.1038/sj.gene.6364316. Epub 2006 Jun 15.

Reference Type BACKGROUND

PMID: 16775618 (View on PubMed)

Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet. 2006 Mar;14(3):364-71. doi: 10.1038/sj.ejhg.5201566.

Reference Type BACKGROUND

PMID: 16418737 (View on PubMed)

Nolsoe RL, Kelly JA, Pociot F, Moser KL, Kristiansen OP, Mandrup-Poulsen T, Harley JB. Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia. Genes Immun. 2005 Dec;6(8):699-706. doi: 10.1038/sj.gene.6364259.

Reference Type BACKGROUND

PMID: 16163374 (View on PubMed)

Xing C, Gray-McGuire C, Kelly JA, Garriott P, Bukulmez H, Harley JB, Olson JM. Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum Genet. 2005 Dec;118(3-4):309-21. doi: 10.1007/s00439-005-0061-5. Epub 2005 Sep 28.

Reference Type BACKGROUND

PMID: 16189706 (View on PubMed)

Lee YH, Witte T, Momot T, Schmidt RE, Kaufman KM, Harley JB, Sestak AL. The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum. 2005 Dec;52(12):3966-74. doi: 10.1002/art.21484.

Reference Type BACKGROUND

PMID: 16320344 (View on PubMed)

Namjou B, Kelly JA, Kilpatrick J, Kaufman KM, Nath SK, Scofield RH, Harley JB. Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease. Arthritis Rheum. 2005 Nov;52(11):3646-50. doi: 10.1002/art.21413.

Reference Type BACKGROUND

PMID: 16255059 (View on PubMed)

Sestak AL, Nath SK, Harley JB. Genetics of systemic lupus erythematosus: how far have we come? Rheum Dis Clin North Am. 2005 May;31(2):223-44, v. doi: 10.1016/j.rdc.2005.01.005.

Reference Type BACKGROUND

PMID: 15922143 (View on PubMed)

Harley JB, Moser KL, Gaffney PM, Behrens TW. The genetics of human systemic lupus erythematosus. Curr Opin Immunol. 1998 Dec;10(6):690-6. doi: 10.1016/s0952-7915(98)80090-3.

Reference Type RESULT

PMID: 9914226 (View on PubMed)

Moser KL, Gray-McGuire C, Kelly J, Asundi N, Yu H, Bruner GR, Mange M, Hogue R, Neas BR, Harley JB. Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41. Arthritis Rheum. 1999 Sep;42(9):1902-7. doi: 10.1002/1529-0131(199909)42:93.0.CO;2-G.

Reference Type RESULT

PMID: 10513806 (View on PubMed)

Rao S, Olson JM, Moser KL, Gray-McGuire C, Bruner GR, Kelly J, Harley JB. Linkage analysis of human systemic lupus erythematosus-related traits: a principal component approach. Arthritis Rheum. 2001 Dec;44(12):2807-18. doi: 10.1002/1529-0131(200112)44:123.0.co;2-c.

Reference Type RESULT

PMID: 11762941 (View on PubMed)

Tsao BP, Grossman JM, Riemekasten G, Strong N, Kalsi J, Wallace DJ, Chen CJ, Lau CS, Ginzler EM, Goldstein R, Kalunian KC, Harley JB, Arnett FC, Hahn BH, Cantor RM. Familiality and co-occurrence of clinical features of systemic lupus erythematosus. Arthritis Rheum. 2002 Oct;46(10):2678-85. doi: 10.1002/art.10519.

Reference Type RESULT

PMID: 12384927 (View on PubMed)

Namjou B, Nath SK, Kilpatrick J, Kelly JA, Reid J, James JA, Harley JB. Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Arthritis Rheum. 2002 Nov;46(11):2937-45. doi: 10.1002/art.10588.

Reference Type RESULT

PMID: 12428235 (View on PubMed)

Scofield RH, Bruner GR, Kelly JA, Kilpatrick J, Bacino D, Nath SK, Harley JB. Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood. 2003 Feb 1;101(3):992-7. doi: 10.1182/blood-2002-04-1003. Epub 2002 Sep 12.

Reference Type RESULT

PMID: 12393658 (View on PubMed)

Heinlen LD, McClain MT, Kim X, Quintero DR, James JA, Harley JB, Scofield RH. Anti-Ro and anti-nRNP response in unaffected family members of SLE patients. Lupus. 2003;12(4):335-7. doi: 10.1191/0961203303lu377xx. No abstract available.

Reference Type RESULT

PMID: 12729062 (View on PubMed)

Nath SK, Quintero-Del-Rio AI, Kilpatrick J, Feo L, Ballesteros M, Harley JB. Linkage at 12q24 with systemic lupus erythematosus (SLE) is established and confirmed in Hispanic and European American families. Am J Hum Genet. 2004 Jan;74(1):73-82. doi: 10.1086/380913. Epub 2003 Dec 4.

Reference Type RESULT

PMID: 14658095 (View on PubMed)

Nath SK, Kilpatrick J, Harley JB. Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol. 2004 Dec;16(6):794-800. doi: 10.1016/j.coi.2004.09.007.

Reference Type RESULT

PMID: 15511675 (View on PubMed)

Sawalha AH, Harley JB. Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol. 2004 Sep;16(5):534-40. doi: 10.1097/01.bor.0000135452.62800.8f.

Reference Type RESULT

PMID: 15314490 (View on PubMed)

Quintero-del-Rio AI, Kelly JA, Garriott CP, Hutchings DC, Frank SG, Aston CE, Harley JB. SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis. Am J Hum Genet. 2004 Aug;75(2):346-8. doi: 10.1086/422460. No abstract available.

Reference Type RESULT

PMID: 15307049 (View on PubMed)

Sawalha AH, Schmid WR, Binder SR, Bacino DK, Harley JB. Association between systemic lupus erythematosus and Helicobacter pylori seronegativity. J Rheumatol. 2004 Aug;31(8):1546-50.

Reference Type RESULT

PMID: 15290733 (View on PubMed)

Nath SK, Kelly JA, Harley JB, Scofield RH. Mapping the systematic lupus erythematosus susceptibility genes. Methods Mol Med. 2004;102:11-29. doi: 10.1385/1-59259-805-6:011.

Reference Type RESULT

PMID: 15286378 (View on PubMed)

Nath SK, Namjou B, Garriott CP, Frank S, Joslin PA, Kilpatrick J, Kelly JA, Harley JB. Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. Genes Immun. 2004 May;5(3):209-14. doi: 10.1038/sj.gene.6364060.

Reference Type RESULT

PMID: 15014430 (View on PubMed)

Nath SK, Namjou B, Kilpatrick J, Garriott CP, Bruner GR, Scofield RH, Harley JB. A candidate region on 11p13 for systemic lupus erythematosus: a linkage identified in African-American families. J Investig Dermatol Symp Proc. 2004 Jan;9(1):64-7. doi: 10.1111/j.1087-0024.2004.00830.x.

Reference Type RESULT

PMID: 14870988 (View on PubMed)

Nath SK, Namjou B, Hutchings D, Garriott CP, Pongratz C, Guthridge J, James JA. Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity. Eur J Hum Genet. 2004 Aug;12(8):668-72. doi: 10.1038/sj.ejhg.5201209.

Reference Type RESULT

PMID: 15114372 (View on PubMed)

Lee YH, Harley JB, Nath SK. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet. 2005 Apr;116(5):361-7. doi: 10.1007/s00439-004-1244-1. Epub 2005 Feb 2.

Reference Type RESULT

PMID: 15688186 (View on PubMed)

Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet. 2005 May;37(5):478-85. doi: 10.1038/ng1540. Epub 2005 Apr 17.

Reference Type RESULT

PMID: 15838509 (View on PubMed)