Cerebral Hemodynamics in Sleep Disorders

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-05-31

Study Completion Date

2018-10-26

Brief Summary

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The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.

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Detailed Description

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Sleep disorders continue to be the most unrecognized modifiable risk factor for stroke. The relationship between sleep disorders and vascular risk factors and stroke has been well-documented but not fully understood. The investigators hypothesize hemodynamics impairment to be its potential mechanism. It has been reported that sleep-related breathing disorder, a type of sleep disorders, contributed as a risk factor for stroke through hemodynamic and hematologic changes. The purpose of this study is to determine the relationship between different kind of sleep disorders and cerebral hemodynamics, including OSHAS, RLS, RBD, narcolepsy, etc. The dynamic cerebral auto-regulation (dCA) and Transcranial Doppler (TCD) will be used to evaluate cerebral hemodynamics.

Conditions

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Sleep Disorders, Intrinsic

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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patients with sleep disorders

No interventions assigned to this group

normal individuals without sleep disorders

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients with sleep disorders
* meet the Diagnostic Criteria for Sleep Dyssomnias
* sufficient bilateral temporal bone windows for insonation of the MCA

Exclusion Criteria

* middle cerebral artery (MCA) and/or other intracranial and/or extracranial major vascular 4 stenosis/occlusion, as diagnosed by a transcranial Doppler
* having a prior symptomatic cerebral vascular disease
* current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability
* inability to cooperate sufficiently to complete the dCA examination

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes