Verification of Computerized Sleep-wake Analysis in Sleep Disorders

NCT ID: NCT02412527

Last Updated: 2015-04-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

330 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-04-30

Brief Summary

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Objective: Computerized sleep staging has been verified in a normal population. This study attempts to investigate and verify the interpretation of this computerized sleep staging program in patients with sleep disorders, and improve the accuracy of actigraphy algorithm for sleep duration and postures.

1. Compare the accuracy of computerized sleep-wake analysis with current sleep quality indicators: through actigraphy and heart rate sensors, compare the computerized sleep-wake analysis program with polysomnography, and verify its clinical reliability and validity in sleep disorder patients.
2. Establish the sleep posture detection system: through three-axis accelerometer, develop algorithms for position recording and monitoring during sleep, and upgrade its accuracy according to photography.

Methods: Patients ranged from age 20-50 with primary insomnia, periodic limb movement in sleep, simple snores, and obstructive sleep apnea will be enrolled in our study. Routine polysomnography will be applied in sleep center at Chang Gung Memorial Hospital, Taoyuan, as well as sleep-related questionnaires. At the same time, actigraphy and heart rate sensor patch will be used for sleep posture detection and further computerized sleep-wake analysis. Results will be verified the consistency by comparison with sleep-wake analysis from polysomnographic data and sleep-related questionnaires.

Detailed Description

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Conditions

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Sleep-wake Analysis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Primary insomnia

Primary insomnia patients, without combined any other sleep disorders

Patch III heart rate sensor

Intervention Type OTHER

Periodic limb movement in sleep

Patients have periodic limb movement in sleep, without combined any other sleep disorders

Patch III heart rate sensor

Intervention Type OTHER

Simple snores

Simple snore patients, without combined any other sleep disorders

Patch III heart rate sensor

Intervention Type OTHER

Obstructive sleep apnea

Obstructive sleep apnea patients, including mild, moderate and severe types, without combined any other sleep disorders or CPAP treatment during PSG study

Patch III heart rate sensor

Intervention Type OTHER

Interventions

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Patch III heart rate sensor

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age 20-50
* diagnosed as primary insomnia, periodic limb movement in sleep, simple snores, and obstructive sleep apnea

Exclusion Criteria

* arrhythmia
* sleep efficiency\<50%
* combined other sleep disorders
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Yang Ming Chiao Tung University

OTHER

Sponsor Role collaborator

Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Geng-Hao Liu

Attending physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Geng-Hao Liu

Role: CONTACT

+886-3-3196200 ext. 2613

References

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Yang CC, Lai CW, Lai HY, Kuo TB. Relationship between electroencephalogram slow-wave magnitude and heart rate variability during sleep in humans. Neurosci Lett. 2002 Aug 30;329(2):213-6. doi: 10.1016/s0304-3940(02)00661-4.

Reference Type RESULT
PMID: 12165415 (View on PubMed)

Kuo TB, Yang CC. Frequency domain analysis of electrooculogram and its correlation with cardiac sympathetic function. Exp Neurol. 2009 May;217(1):38-45. doi: 10.1016/j.expneurol.2009.01.012. Epub 2009 Jan 31.

Reference Type RESULT
PMID: 19416676 (View on PubMed)

Kuo TB, Chen CY, Hsu YC, Yang CC. Performance of the frequency domain indices with respect to sleep staging. Clin Neurophysiol. 2012 Jul;123(7):1338-45. doi: 10.1016/j.clinph.2011.11.003. Epub 2011 Dec 5.

Reference Type RESULT
PMID: 22153785 (View on PubMed)

Sadeh A. The role and validity of actigraphy in sleep medicine: an update. Sleep Med Rev. 2011 Aug;15(4):259-67. doi: 10.1016/j.smrv.2010.10.001. Epub 2011 Jan 14.

Reference Type RESULT
PMID: 21237680 (View on PubMed)

Lindemann U, Hock A, Stuber M, Keck W, Becker C. Evaluation of a fall detector based on accelerometers: a pilot study. Med Biol Eng Comput. 2005 Sep;43(5):548-51. doi: 10.1007/BF02351026.

Reference Type RESULT
PMID: 16411625 (View on PubMed)

Paquet J, Kawinska A, Carrier J. Wake detection capacity of actigraphy during sleep. Sleep. 2007 Oct;30(10):1362-9. doi: 10.1093/sleep/30.10.1362.

Reference Type RESULT
PMID: 17969470 (View on PubMed)

Cole RJ, Kripke DF, Gruen W, Mullaney DJ, Gillin JC. Automatic sleep/wake identification from wrist activity. Sleep. 1992 Oct;15(5):461-9. doi: 10.1093/sleep/15.5.461.

Reference Type RESULT
PMID: 1455130 (View on PubMed)

Tryon WW. Issues of validity in actigraphic sleep assessment. Sleep. 2004 Feb 1;27(1):158-65. doi: 10.1093/sleep/27.1.158.

Reference Type RESULT
PMID: 14998254 (View on PubMed)

Hedner J, Pillar G, Pittman SD, Zou D, Grote L, White DP. A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients. Sleep. 2004 Dec 15;27(8):1560-6. doi: 10.1093/sleep/27.8.1560.

Reference Type RESULT
PMID: 15683148 (View on PubMed)

Murayama R, Kubota T, Kogure T, Aoki K. The effects of instruction regarding sleep posture on the postural changes and sleep quality among middle-aged and elderly men: a preliminary study. Biosci Trends. 2011;5(3):111-9. doi: 10.5582/bst.2011.v5.3.111.

Reference Type RESULT
PMID: 21788696 (View on PubMed)

Wrzus C, Brandmaier AM, von Oertzen T, Muller V, Wagner GG, Riediger M. A new approach for assessing sleep duration and postures from ambulatory accelerometry. PLoS One. 2012;7(10):e48089. doi: 10.1371/journal.pone.0048089. Epub 2012 Oct 24.

Reference Type RESULT
PMID: 23110178 (View on PubMed)

Bignold JJ, Mercer JD, Antic NA, McEvoy RD, Catcheside PG. Accurate position monitoring and improved supine-dependent obstructive sleep apnea with a new position recording and supine avoidance device. J Clin Sleep Med. 2011 Aug 15;7(4):376-83. doi: 10.5664/JCSM.1194.

Reference Type RESULT
PMID: 21897774 (View on PubMed)

de Souza L, Benedito-Silva AA, Pires ML, Poyares D, Tufik S, Calil HM. Further validation of actigraphy for sleep studies. Sleep. 2003 Feb 1;26(1):81-5. doi: 10.1093/sleep/26.1.81.

Reference Type RESULT
PMID: 12627737 (View on PubMed)

Silber MH, Ancoli-Israel S, Bonnet MH, Chokroverty S, Grigg-Damberger MM, Hirshkowitz M, Kapen S, Keenan SA, Kryger MH, Penzel T, Pressman MR, Iber C. The visual scoring of sleep in adults. J Clin Sleep Med. 2007 Mar 15;3(2):121-31.

Reference Type RESULT
PMID: 17557422 (View on PubMed)

Ahlberg K, Savolainen A, Paju S, Hublin C, Partinen M, Kononen M, Ahlberg J. Bruxism and sleep efficiency measured at home with wireless devices. J Oral Rehabil. 2008 Aug;35(8):567-71. doi: 10.1111/j.1365-2842.2008.01875.x. Epub 2008 May 9.

Reference Type RESULT
PMID: 18482341 (View on PubMed)

Other Identifiers

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103-5603B

Identifier Type: -

Identifier Source: org_study_id

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