Embryo Selection by Metabolomic Profiling of Embryo Culture Medium With Mass Spectroscopy as an Adjunct to Morphology
NCT ID: NCT02698488
Last Updated: 2016-08-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2016-10-31
2017-12-31
Brief Summary
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Recently mass spectroscopic (MS) approaches have been utilized in limited settings. Samples needed minimal preparation; analytical analysis was rapid and large amounts of data was available. Hence, MS might be a promising approach for metabolomic profiling of embryo culture media.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Embryo Selection by Morphology
Embryos will be morphologically evaluated according to the number and regularity of blastomeres and fragmentation degree. Only embryo culture media of good quality embryos (embryos with ≥6 cells with no fragmentation) will be included in the study
Morphology
Morphology and Mass Spectroscopy
Embryo Selection by Morphology and Mass Spectroscopy
Embryos will be morphologically evaluated according to the number and regularity of blastomeres and fragmentation degree. Only embryo culture media of good quality embryos (embryos with ≥6 cells with no fragmentation) will be included in the study. After dilution, embryo culture media will be analyzed by electrospray ionization quadrupole time-of-flight (ESI-QTOF) MS. The spectra will be collected in the negative ion mode. Abundance of ions in each spectrum will be further analyzed.
Morphology
Morphology and Mass Spectroscopy
Interventions
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Morphology
Morphology and Mass Spectroscopy
Eligibility Criteria
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Inclusion Criteria
* good previous response to IVF with ≥1 embryo
Exclusion Criteria
21 Years
38 Years
FEMALE
No
Sponsors
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Acibadem Fulya Hospital
OTHER
Marmara University
OTHER
Istanbul University
OTHER
Responsible Party
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Ercan Bastu
Associate Professor of Obstetrics and Gynecology
Principal Investigators
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Ercan Bastu, M.D.
Role: PRINCIPAL_INVESTIGATOR
Istanbul University School of Medicine
Locations
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Istanbul University School of Medicine
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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201603
Identifier Type: -
Identifier Source: org_study_id
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