Oxidative Stress in OR Personnel

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2016-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is investigate to the effect(s) of chronic occupational exposure to N20 and volatile anesthetics on the extent of oxidative stress (DNA damage and the generation of the biochemical markers) in operating room staff, with different levels of exposure to halogenated hydrocarbons, in comparison to unexposed controls (Intensive Care Staff), and to determine the relationship between the degree of oxidative stress and psychological stress, as assessed by validated psychometric measures.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia

NCT04310748

Oxidative Stress Anesthesia

COMPLETED NA

Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

NCT04808401

Coronary Artery Disease Anesthesia

RECRUITING NA

Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers

NCT05099523

Stress Hyperoxia

COMPLETED NA

Local Assessment of Ventilatory Management During General Anesthesia for Surgery

NCT01601223

Surgery Anaesthesia Ventilator-Induced Lung Injury +5 more

COMPLETED

Comparison of Oxidants and Antioxidants in Breastmilk Under Different Anesthesia Protocols

NCT06811714

Oxidative Stress

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a single blinded randomized, controlled and prospective clinical trial comparing oxidative stress status in two groups.

Subjects in two groups will be matched for gender, age, smoking habit and employment duration and will be randomized into one of the two groups of:

1. Pediatric OR Staff, and
2. control (e.g; ICU staff)

Biomarkers of oxidative stress will be measured in two different time points in each subject, (Monday Morning and, Friday afternoon of that same week-\>40 hours in Operating room or Intensive Care Unit).

The relationship between oxidative stress and psychological stress will also be assessed by validated psychometric measures.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Oxidative Stress

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Pediatric Operating Room (OR) Staff

OR Staff exposed to nitrous oxide, and other volatile anesthetics

Exposure to nitrous oxide or other volatile anesthetics

Intervention Type OTHER

No intervention, but routine work-place exposure to volatile anesthetics

Pediatric Intensive Care Unit (ICU) Staff

ICU Staff unexposed to any volatile anesthetics

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Exposure to nitrous oxide or other volatile anesthetics

No intervention, but routine work-place exposure to volatile anesthetics

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. CHOR-Staff who work \> 40 hours per week in the operating rooms (Anesthesiologists, CRNA, Surgeons, Nurses)
2. NOR- Intensive Care Unit Staff who work \> 40 hours per week in Intensive care unit (Physicians, Nurses, APN'S)

Exclusion Criteria

Staff with the following history will be excluded:

1. Therapeutic exposure to radiation
2. On chemotherapeutic agents
3. History of General Anesthesia during the past two years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes