Hyperoxic Oxidative Stress During Abdominal Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2013-05-31

Brief Summary

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Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

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Detailed Description

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Conditions

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Response to Hyperoxia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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40% oxygen

Patients in this group will be ventilated with fraction of inspired oxygen 40% during the surgery.

Group Type ACTIVE_COMPARATOR

Fraction of inspired oxygen 40%

Intervention Type OTHER

80% oxygen

Patients in this group will be ventilated with a fraction of inspired oxygen 80% during the surgery.

Group Type ACTIVE_COMPARATOR

Fraction of inspired oxygen 80%

Intervention Type OTHER

Interventions

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Fraction of inspired oxygen 40%

Intervention Type OTHER

Fraction of inspired oxygen 80%

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II

Exclusion Criteria

* Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition.

Patients will be recruited through general surgery service of our hospital

Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No