The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-11-01

Brief Summary

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We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Detailed Description

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Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Conditions

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Cardiovascular Diseases

Keywords

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cardiovascular surgery antioxidant tiyol-disülfid homeostasis ischemia modified albumin

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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group 1

Group 1: Pressure of arterial oxygen\> 200 mmHg during the coronary surgery

taken venous sample

Intervention Type DIAGNOSTIC_TEST

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

group 2

Group 2: Pressure of arterial oxygen\<200 mmHg and \>80 mmHg during the coronary surgery

taken venous sample

Intervention Type DIAGNOSTIC_TEST

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

Interventions

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taken venous sample

Venous blood samples taken during the operation and at the 48th hour after the operation will be examined after appropriate procedures.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patient scheduled for cardiac surgery
* ASA\>3
* Aged 18-75 years

Exclusion Criteria

* those with valvular disease
* EF\<%40
* BMI\>40 kg/m2
* presence of arrhythmia that impairs hemodynamics
* previous history of cerebrovascular
* diagnosed with end-stage organ failure

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Umran Karaca

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR