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Bronchospasm Associated With High Nitric Oxide

NCT ID: NCT00666510

Last Updated: 2008-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

31 participants

Study Classification

OBSERVATIONAL

Study Start Date

1999-01-31

Study Completion Date

2004-12-31

Brief Summary

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Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Detailed Description

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Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Conditions

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Asthma Airway Hyperresponsiveness

Keywords

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nitric oxide bronchospasm anesthesia induced sputum asthma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Bronchospasm

Patients who presented bronchospasm during anesthesia induction

No interventions assigned to this group

Asthma

Patients who presented bronchospasm during anesthesia induction and were identified as asthmatics

No interventions assigned to this group

Control

Patients who were submitted to anesthesia induction and showed no complications

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion Criteria

* hypertension, COPD, diabetes, pregnancy
Minimum Eligible Age

16 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Fisiopatologia Experimental FMUSP

Principal Investigators

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Joaquim E Vieira, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo Medical School - FMUSP

Locations

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Hospital das Clínicas da FMUSP

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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CAP125-01

Identifier Type: -

Identifier Source: org_study_id