Local Assessment of Ventilatory Management During General Anesthesia for Surgery
NCT ID: NCT01601223
Last Updated: 2015-10-14
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Total Enrollment
10690 participants
Study Classification
OBSERVATIONAL
Study Start Date
2013-01-31
Study Completion Date
2013-11-30
Brief Summary
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Objectives
1. To characterize mechanical ventilation practices during general anesthesia for surgery
2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical Ventilation (MV) settings
1. To characterize mechanical ventilation practices during general anesthesia for surgery
2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical Ventilation (MV) settings
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Detailed Description
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Research questions
* What MV-settings are used during general anesthesia for surgery?
* Do MV-settings vary in and/or between centers?
* Do MV-settings vary internationally?
* Are MV-settings associated with incidence of intra-operative pulmonary complications?
* Are MV-settings associated with incidence of post-operative pulmonary complications?
* What MV-settings are used during general anesthesia for surgery?
* Do MV-settings vary in and/or between centers?
* Do MV-settings vary internationally?
* Are MV-settings associated with incidence of intra-operative pulmonary complications?
* Are MV-settings associated with incidence of post-operative pulmonary complications?
Conditions
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Surgery
Anaesthesia
Ventilator-Induced Lung Injury
Lung Injury
Pneumonia
Pneumothorax
Respiratory Distress Syndrome, Adult
Respiratory Insufficiency
Study Design
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Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Study Groups
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Surgical mechanically-ventilated
Surgical patients undergoing invasive mechanical ventilation for general anesthesia
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age ≥ 18 years
* All surgical procedures requiring invasive mechanical ventilation (MV)during general anesthesia for laparoscopic or non-laparoscopic surgery.
* This includes MV performed with supra-glottic devices (e.g. laryngeal mask)
* This includes patients receiving MV at the onset of the procedure (e.g. Intensive Care Unit patients)
* This includes patients who will receive one-lung ventilation during the procedure
* All surgical procedures requiring invasive mechanical ventilation (MV)during general anesthesia for laparoscopic or non-laparoscopic surgery.
* This includes MV performed with supra-glottic devices (e.g. laryngeal mask)
* This includes patients receiving MV at the onset of the procedure (e.g. Intensive Care Unit patients)
* This includes patients who will receive one-lung ventilation during the procedure
Exclusion Criteria
* Obstetric surgical procedures or any procedure during pregnancy
* Surgical procedures outside the operating room
* Surgical procedures involving extra-corporal circulation
* Surgical procedures outside the operating room
* Surgical procedures involving extra-corporal circulation
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER
Sponsor Role
collaborator
European Society of Anaesthesiology
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Schultz Marcus, MD
Role: STUDY_CHAIR
AMC, Amsterdam, The Netherlands
Sabrine Hemmes, MD
Role: STUDY_DIRECTOR
AMC, Amsterdam, The Netherlands
Locations
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University of Colorado School of Medicine/University of Colorado Hospital
Aurora, Colorado, United States
Site Status
Massachusetts General Hospital
Boston, Massachusetts, United States
Site Status
Mayo Clinic
Rochester, Minnesota, United States
Site Status
North Estonia Medical Center
Tallinn, , Estonia
Site Status
Tartu University Hospital
Tartu, , Estonia
Site Status
University Hospital Carl Gustav Carus, Dresden University of Technonology, Department of Anesthesiology and Intensive Care Therapy
Dresden, , Germany
Site Status
Duesseldorf University Hospital
Düsseldorf, , Germany
Site Status
Diakoniekrankenhaus Friederikenstift
Hanover, , Germany
Site Status
Ospedale San Martino, Dipartimento di scienze chirurgiche e diagnostiche integrate
Genoa, , Italy
Site Status
Ospedale San Raffaele
Milan, , Italy
Site Status
Vilnius University Hospital - Institute of Oncology
Vilnius, , Lithuania
Site Status
Vilnius University Hospital - Santariskiu Clinics
Vilnius, , Lithuania
Site Status
Academic Medical Center, University of Amsterdam
Amsterdam, , Netherlands
Site Status
VU University Medical Center
Amsterdam, , Netherlands
Site Status
MC Haaglanden
The Hague, , Netherlands
Site Status
Haukeland University Hospital
Bergen, , Norway
Site Status
Førde Central Hospital /Førde Sentral Sykehus
Førde, , Norway
Site Status
Institute of Oncology Ljubljana
Ljubljana, , Slovenia
Site Status
University Medicine Centre Ljubljana
Ljubljana, , Slovenia
Site Status
Countries
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United States
Estonia
Germany
Italy
Lithuania
Netherlands
Norway
Slovenia
References
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Hemmes SN, de Abreu MG, Pelosi P, Schultz MJ. ESA Clinical Trials Network 2012: LAS VEGAS--Local Assessment of Ventilatory Management during General Anaesthesia for Surgery and its effects on Postoperative Pulmonary Complications: a prospective, observational, international, multicentre cohort study. Eur J Anaesthesiol. 2013 May;30(5):205-7. doi: 10.1097/EJA.0b013e32835fcab3. No abstract available.
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BACKGROUND
Dorland G, Saadat W, van Meenen DMP, Neto AS, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Schmid W, Severgnini P, Wrigge H, de Abreu MG, Schultz MJ, Hemmes SNT; LAS VEGAS-investigators. Association of preoperative smoking with the occurrence of postoperative pulmonary complications: A post hoc analysis of an observational study in 29 countries. J Clin Anesth. 2025 Jun;104:111856. doi: 10.1016/j.jclinane.2025.111856. Epub 2025 May 14.
Reference Type
DERIVED
Nasa P, van Meenen DMP, Paulus F, de Abreu MG, Bossers SM, Schober P, Schultz MJ, Neto AS, Hemmes SNT; LAS VEGAS-investigators; PROVE Network; ESAIC CTN; LAS VEGAS collaborators. Associations of intraoperative end-tidal CO2 levels with postoperative outcome-secondary analysis of a worldwide observational study. J Clin Anesth. 2025 Feb;101:111728. doi: 10.1016/j.jclinane.2024.111728. Epub 2024 Dec 19.
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DERIVED
Vermeulen TD, Hol L, Swart P, Hiesmayr M, Mills GH, Putensen C, Schmid W, Serpa Neto A, Severgnini P, Vidal Melo MF, Wrigge H, Hollmann MW, Gama de Abreu M, Schultz MJ, Hemmes SN, van Meenen DM; LAS VEGAS Collaborators group; PROVEnet; Clinical Trial Network of the European Society of Anaesthesiology. Sex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS. J Clin Anesth. 2024 Dec;99:111565. doi: 10.1016/j.jclinane.2024.111565. Epub 2024 Sep 23.
Reference Type
DERIVED
Serafini SC, Hemmes SNT, Serpa Neto A, Schultz MJ, Tschernko E, Gama de Abreu M, Mazzinari G, Ball L; LAS VEGAS - and the AVATaR - investigators. Risk factors for PPCs in laparoscopic non-robotic vs. laparoscopic robotic abdominal surgery (LapRas): rationale and protocol for a patient-level analysis of LAS VEGAS and AVATaR. Rev Esp Anestesiol Reanim (Engl Ed). 2024 Oct;71(8):592-600. doi: 10.1016/j.redare.2024.07.001. Epub 2024 Jul 8.
Reference Type
DERIVED
Hol L, Nijbroek SGLH, Neto AS, Hemmes SNT, Hedenstierna G, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Schmid W, Severgnini P, Wrigge H, de Abreu MG, Pelosi P, Schultz MJ; LAS VEGAS study-investigators. Geo-economic variations in epidemiology, ventilation management and outcome of patients receiving intraoperative ventilation during general anesthesia- posthoc analysis of an observational study in 29 countries. BMC Anesthesiol. 2022 Jan 7;22(1):15. doi: 10.1186/s12871-021-01560-x.
Reference Type
DERIVED
Mazzinari G, Serpa Neto A, Hemmes SNT, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Pearse RM, Putensen C, Schmid W, Severgnini P, Wrigge H, Cambronero OD, Ball L, de Abreu MG, Pelosi P, Schultz MJ; LAS VEGAS study-investigators; PROtective VEntilation NETwork; Clinical Trial Network of the European Society of Anaesthesiology. The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study. BMC Anesthesiol. 2021 Mar 19;21(1):84. doi: 10.1186/s12871-021-01268-y.
Reference Type
DERIVED
Nijbroek SG, Hol L, Swart P, Hemmes SNT, Serpa Neto A, Binnekade JM, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ; LAS VEGAS study investigators, the PROVE Network and the Clinical Trial Network of the European Society of Anaesthesiology. Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study. Eur J Anaesthesiol. 2021 Oct 1;38(10):1034-1041. doi: 10.1097/EJA.0000000000001476.
Reference Type
DERIVED
Bulte CSE, Boer C, Hemmes SNT, Serpa Neto A, Binnekade JM, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Pearse RM, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ; for the LAS VEGAS; study-investigators; the PROVE Network; and the Clinical Trial Network of the European Society of Anaesthesiology. The effects of preoperative moderate to severe anaemia on length of hospital stay: A propensity score-matched analysis in non-cardiac surgery patients. Eur J Anaesthesiol. 2021 Jun 1;38(6):571-581. doi: 10.1097/EJA.0000000000001412.
Reference Type
DERIVED
Uhlig C, Neto AS, van der Woude M, Kiss T, Wittenstein J, Shelley B, Scholes H, Hiesmayr M, Vidal Melo MF, Sances D, Coskunfirat N, Pelosi P, Schultz M, Gama de Abreu M; LAS VEGAS# investigators, Protective Ventilation Network (PROVEnet), Clinical Trial Network of the European Society of Anaesthesiology. Intraoperative mechanical ventilation practice in thoracic surgery patients and its association with postoperative pulmonary complications: results of a multicenter prospective observational study. BMC Anesthesiol. 2020 Jul 22;20(1):179. doi: 10.1186/s12871-020-01098-4.
Reference Type
DERIVED
Cortegiani A, Gregoretti C, Neto AS, Hemmes SNT, Ball L, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Melo MFV, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Schultz MJ, Pelosi P; LAS VEGAS Investigators, the PROVE Network, and the Clinical Trial Network of the European Society of Anaesthesiology. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications. Br J Anaesth. 2019 Mar;122(3):361-369. doi: 10.1016/j.bja.2018.10.063. Epub 2019 Feb 8.
Reference Type
DERIVED
Ball L, Hemmes SNT, Serpa Neto A, Bluth T, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Schultz MJ, Pelosi P; LAS VEGAS investigators; PROVE Network; Clinical Trial Network of the European Society of Anaesthesiology. Intraoperative ventilation settings and their associations with postoperative pulmonary complications in obese patients. Br J Anaesth. 2018 Oct;121(4):899-908. doi: 10.1016/j.bja.2018.04.021. Epub 2018 Jun 2.
Reference Type
DERIVED
Neto AS, da Costa LGV, Hemmes SNT, Canet J, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Pearse R, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ; LAS VEGAS. The LAS VEGAS risk score for prediction of postoperative pulmonary complications: An observational study. Eur J Anaesthesiol. 2018 Sep;35(9):691-701. doi: 10.1097/EJA.0000000000000845.
Reference Type
DERIVED
LAS VEGAS investigators. Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries. Eur J Anaesthesiol. 2017 Aug;34(8):492-507. doi: 10.1097/EJA.0000000000000646.
Reference Type
DERIVED
Related Links
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https://sites.google.com/site/lasvegasstudy/home
LAS VEGAS Study Specific Website
Other Identifiers
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LAS VEGAS
Identifier Type: -
Identifier Source: org_study_id
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