Impact of OFA During LPV on Postoperative Oxygen Saturation

NCT ID: NCT03660306

Last Updated: 2019-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-08-01

Study Completion Date

2019-11-05

Brief Summary

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Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.

Detailed Description

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This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise.

Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019.

A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU..

If post operative satuation drops below 94% oxygen therapy is given and noted.

Conditions

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Decreased Lung Compliance Oxygen Requirement

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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opioid anesthesia

classical anesthesia using sufentanil to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

opioid anesthesia

Intervention Type PROCEDURE

opioid anesthesia means using sufentanil during surgery

opioid free anesthesia

anesthesia using non opioids like dexmedetomidine, lidocaine, magnesium and ketamine to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

opioid free anesthesia

Intervention Type PROCEDURE

opioid free anesthesia means giving no opioids during surgery

Interventions

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opioid anesthesia

opioid anesthesia means using sufentanil during surgery

Intervention Type PROCEDURE

opioid free anesthesia

opioid free anesthesia means giving no opioids during surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* major surgery where intubation with mechanical ventilation is required
* obese patients with BMI \> 35

Exclusion Criteria

* spontaneous breathing during procedure
* allergic to any of the drugs used in both groups
* severe liver, renal, cardiac or pulmonary disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AZ Sint-Jan AV

OTHER

Sponsor Role lead

Responsible Party

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Jan Mulier

MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Marco Lanckneus, MD

Role: STUDY_DIRECTOR

AZ Sint-Jan AV

Locations

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Azsintjan

Bruges, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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OS impact OFA on SAT d LPV

Identifier Type: -

Identifier Source: org_study_id

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