Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients

NCT ID: NCT02604082

Last Updated: 2015-11-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 93 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-09-30
• Study Completion Date: 2015-11-30

Brief Summary

Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Detailed Description

Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Conditions

Mucociliary Clearance Defect; Physical Disability

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Vibocompression (VB)

Grup 1 - Vibrocompression: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration

Group Type: ACTIVE_COMPARATOR

Vibrocompression (VB)

Intervention Type: OTHER

Vibrocompression is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation (MV)

Hyperinflation (HMV)

Grup 2 - Hyperinflation with Mechanical ventilator: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the increase in inspiratory pressure ventilator .

Group Type: ACTIVE_COMPARATOR

Hyperinflation (HMV)

Intervention Type: OTHER

Hyperinflation technique with mechanical ventilator which aims to clear the airways of patients on mechanical ventilation

HMV+VB

Grup 3 - Hyperinflation with mechanical ventilator and vibrocompression:Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration and the increase in inspiratory pressure ventilator.

Group Type: EXPERIMENTAL

HMV+VB

Intervention Type: OTHER

Association between Vibrocompression and Hyperinflation with mechanical ventilator

Interventions

Vibrocompression (VB)

Vibrocompression is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation (MV)

Intervention Type: OTHER

Hyperinflation (HMV)

Hyperinflation technique with mechanical ventilator which aims to clear the airways of patients on mechanical ventilation

Intervention Type: OTHER

HMV+VB

Association between Vibrocompression and Hyperinflation with mechanical ventilator

Intervention Type: OTHER

Other Intervention Names

Techinique of physical therapy; Techinique of physical therapy; Techinique of physical therapy

Eligibility Criteria

Inclusion Criteria

• In mechanical ventilation for a period of 24-72 h
• End-expiratory pressure (PEEP) lower 10 cm of water.
• Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.

Exclusion Criteria

• Pneumothorax and hemothorax undrained
• Subcutaneous emphysema
• Osteoporosis
• Acute respiratory distress syndrome - (ARDS)
• Fractures of ribs
• Obese ( BMI greater than 35)
• Mechanical ventilator with higher peak pressures 40 cm of water.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospital de Clinicas de Porto Alegre

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Silvia R Rios Vieira, Dr

Role: PRINCIPAL_INVESTIGATOR

HCPorto Alegre, Rio Grande do Sul - Brazil

References

Naue Wda S, Forgiarini Junior LA, Dias AS, Vieira SR. Chest compression with a higher level of pressure support ventilation: effects on secretion removal, hemodynamics, and respiratory mechanics in patients on mechanical ventilation. J Bras Pneumol. 2014 Jan-Feb;40(1):55-60. doi: 10.1590/S1806-37132014000100008.

Reference Type: RESULT

PMID: 24626270 (View on PubMed)

Other Identifiers

11-0367

Identifier Type: -

Identifier Source: org_study_id