Ventilator Hyperinflation and Manual Rib Cage Compression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-28

Study Completion Date

2017-07-11

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a randomized crossover trial to evaluate the effects of thoracic compression applied alone or in association with hyperinflation maneuver with the ventilator. In addition, the mobilized volume and peak expiratory flow resulting from both maneuvers will be evaluated.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation

NCT03464071

Sepsis

UNKNOWN NA

Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients

NCT06791798

Mechanically Ventilated Patients Lung Compliance Airway Clearance Impairment

RECRUITING NA

Ventilator Hyperinflation With Increase of Inspiratory Time

NCT03630510

Lung Infection Mechanical Ventilation

COMPLETED NA

Efficacy and Ventilatory Responses to VHI in Atelectasis Patients

NCT02768350

Atelectasis

COMPLETED NA

Comparison Between Different Ventilator Hyperinflation Maneuvers

NCT03631342

Infections, Respiratory Ventilator Associated Pneumonia

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Ventilator hyperinflation is widely used in hypersecretive patients. It consists of increasing alveolar ventilation by facilitating the coughing mechanism so that the secretions of the peripheral airways are mobilized into the central airways so that they can be removed by tracheal aspiration or cough. Thoracic compression consists of manually compressing the rib cage during expiration, in order to increase expiratory flow, mobilize and remove pulmonary secretions. A randomized crossover clinical trial was performed with 30 patients submitted to isolated compression or associated with ventilator hyperinflation, with a 6 hour interval. Patients were evaluated through compliance and resistance of the respiratory system.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pulmonary Atelectasis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Expiratory Rib Cage Compression

Expiratory rib cage compression was performed in 6 sets of 6 cycles, with 1 cycle interval. Ventilatory mode and parameters were maintained.

Group Type ACTIVE_COMPARATOR

Expiratory Rib Cage Compression

Intervention Type OTHER

Compression was performed in 6 sets of 6 cycles, with 1 cycle interval. Ventilatory mode and parameters were maintained.

Compression + Ventilator Hyperinflation

Expiratory rib cage compression was performed in 6 sets of 6 cycles, with 1 cycle interval. Ventilator hyperinflation was performed by increasing the inspiratory pressure to every 5 cmH2O until the total pressure reached 40 cmH2O, remaining the same.

Group Type ACTIVE_COMPARATOR

Compression + Ventilator Hyperinflation

Intervention Type OTHER

Mechanical ventilator hyperinflation was performed by increasing the inspiratory pressure to every 5 cmH2O until the total pressure reached 40 cmH2O, remaining the same. In Expiratory Rib Cage Compression associated with ventilator hyperinflation, thoracic compression maneuver was performed at the end of inspiration, at the exact moment of cycling.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Expiratory Rib Cage Compression

Compression was performed in 6 sets of 6 cycles, with 1 cycle interval. Ventilatory mode and parameters were maintained.

Intervention Type OTHER

Compression + Ventilator Hyperinflation

Mechanical ventilator hyperinflation was performed by increasing the inspiratory pressure to every 5 cmH2O until the total pressure reached 40 cmH2O, remaining the same. In Expiratory Rib Cage Compression associated with ventilator hyperinflation, thoracic compression maneuver was performed at the end of inspiration, at the exact moment of cycling.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients under mechanical ventilation
* diagnosis of pulmonary infection
* hypersecretive

Exclusion Criteria

* haemodynamic instability (heart rate \> 130 bpm and mean arterial pressure \< 60 mmHg)
* acute bronchospasm
* acute respiratory distress syndrome
* untreated pneumothorax

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No