Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
NCT ID: NCT02632539
Last Updated: 2015-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE3
220 participants
INTERVENTIONAL
2016-01-31
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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subglottic secretion drainage
The conventional method which we use subglottic secretion drainage to clear subglottic secretion
subglottic secretion drainage
The conventional method which we use subglottic secretion drainage to clear subglottic secretion
Manual air-impingement operation
A method which we invented to clear subglottic secretion
Manual air-impingement operation
A method which we invented to clear subglottic secretion
Interventions
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Manual air-impingement operation
A method which we invented to clear subglottic secretion
subglottic secretion drainage
The conventional method which we use subglottic secretion drainage to clear subglottic secretion
Eligibility Criteria
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Inclusion Criteria
* Anticipated intubation for more than 72 hours;
* Anticipated survival time is more than 2 weeks
Exclusion Criteria
* unstable hemodynamics;
* severe bulla and pneumothorax;
* enrolled in other study;
* cuff leak test is positive.
18 Years
ALL
No
Sponsors
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Beijing Chao Yang Hospital
OTHER
Responsible Party
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Jiwei LI
RRT-NPS
Principal Investigators
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Jiwei Li
Role: PRINCIPAL_INVESTIGATOR
Beijing Chao Yang Hospital
Central Contacts
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References
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Grossman RF, Fein A. Evidence-based assessment of diagnostic tests for ventilator-associated pneumonia. Executive summary. Chest. 2000 Apr;117(4 Suppl 2):177S-181S. doi: 10.1378/chest.117.4_suppl_2.177s. No abstract available.
Damas P, Frippiat F, Ancion A, Canivet JL, Lambermont B, Layios N, Massion P, Morimont P, Nys M, Piret S, Lancellotti P, Wiesen P, D'orio V, Samalea N, Ledoux D. Prevention of ventilator-associated pneumonia and ventilator-associated conditions: a randomized controlled trial with subglottic secretion suctioning. Crit Care Med. 2015 Jan;43(1):22-30. doi: 10.1097/CCM.0000000000000674.
Klompas M. Ventilator-associated pneumonia: is zero possible? Clin Infect Dis. 2010 Nov 15;51(10):1123-6. doi: 10.1086/656738. Epub 2010 Oct 11. No abstract available.
Frost SA, Azeem A, Alexandrou E, Tam V, Murphy JK, Hunt L, O'Regan W, Hillman KM. Subglottic secretion drainage for preventing ventilator associated pneumonia: a meta-analysis. Aust Crit Care. 2013 Nov;26(4):180-8. doi: 10.1016/j.aucc.2013.03.003. Epub 2013 Apr 11.
Ramirez P, Bassi GL, Torres A. Measures to prevent nosocomial infections during mechanical ventilation. Curr Opin Crit Care. 2012 Feb;18(1):86-92. doi: 10.1097/MCC.0b013e32834ef3ff.
Suys E, Nieboer K, Stiers W, De Regt J, Huyghens L, Spapen H. Intermittent subglottic secretion drainage may cause tracheal damage in patients with few oropharyngeal secretions. Intensive Crit Care Nurs. 2013 Dec;29(6):317-20. doi: 10.1016/j.iccn.2013.02.007. Epub 2013 May 31.
Lorente L, Lecuona M, Jimenez A, Mora ML, Sierra A. Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1079-83. doi: 10.1164/rccm.200705-761OC. Epub 2007 Sep 13.
Tao Z, Zhao S, Yang G, Wang L, Zhu S. [Effect of two methods of subglottic secretion drainage on the incidence of ventilator-associated pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi. 2014 Apr;37(4):283-6. Chinese.
Bouza E, Perez MJ, Munoz P, Rincon C, Barrio JM, Hortal J. Continuous aspiration of subglottic secretions in the prevention of ventilator-associated pneumonia in the postoperative period of major heart surgery. Chest. 2008 Nov;134(5):938-946. doi: 10.1378/chest.08-0103. Epub 2008 Jul 18.
Related Links
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Evidence-based assessment of diagnostic tests for ventilator-associated pneumonia.Executive summary
Prevention of ventilator-associated pneumonia and ventilator-associated conditions: a randomized controlled trial with subglottic secretion suctioning.
Ventilator-associated pneumonia: is zero possible?
Subglottic secretion drainage for preventing ventilator associated pneumonia: a meta-analysis.
Measures to prevent nosocomial infections during mechanical ventilation.
Intermittent subglottic secretion drainage may cause tracheal damage in patients with few oropharyngeal secretions.
Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia.
Effect of two methods of subglottic secretion drainage on the incidence of ventilator-associated pneumonia
Continuous aspiration of subglottic secretions in the prevention of ventilator-associated pneumonia in the postoperative period of major heart surgery.
Other Identifiers
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BJCYH-RCCM-01
Identifier Type: -
Identifier Source: org_study_id