Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation
NCT ID: NCT03464175
Last Updated: 2022-11-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
34 participants
INTERVENTIONAL
2018-01-22
2020-12-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Heated-humidifier left on during nebulization
Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Heated-humidified circuit
It will be left on during the transfer and the nebulization in group 1
Heated-humidifier turned off 30 minutes before nebulization
Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Heated-humidified circuit
It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).
Use of a heat and moisture exchanger (HME) filter
Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Conventional dry ventilator circuit with HME filter
The nebulizer is placed between the filter and the endotracheal tube.
Use of a dry ventilator circuit specific for aerosol therapy
Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Dry ventilator circuit specific for aerosol therapy
Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece
Interventions
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Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Heated-humidified circuit
It will be left on during the transfer and the nebulization in group 1
Heated-humidified circuit
It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).
Dry ventilator circuit specific for aerosol therapy
Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece
Conventional dry ventilator circuit with HME filter
The nebulizer is placed between the filter and the endotracheal tube.
Eligibility Criteria
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Inclusion Criteria
* Postoperative neurosurgery intubated patients admitted for brain neurosurgery in the ICU (Intensive care neuro-traumatologic and Toxicologic)- With a healthy lung function.
* Signed and dated informed consent should be obtained in accordance of local regulations.
Exclusion Criteria
* History of cardiovascular and pulmonary disease
* Extubation immediately after surgery
* Modification of the allocated humidification technique before or during the nebulization (heated-humidifier deficiency or safety concern)
* Inaccurate quantification of aerosol deposition (i.e., artifacts or overlap of tracheal and pulmonary deposition).
18 Years
ALL
No
Sponsors
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Responsible Party
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Principal Investigators
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Pierre-François Laterre, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Locations
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Cliniques Universiataires Saint-Luc
Brussels, , Belgium
Countries
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Other Identifiers
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2017/08NOV/508
Identifier Type: -
Identifier Source: org_study_id
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