Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric

NCT ID: NCT01879488

Last Updated: 2015-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-06-30

Brief Summary

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Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.

The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.

Detailed Description

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Conditions

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Post-operative Neurosurgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Nebulization during pressure support ventilation

Patients ventilated in pressure support mode during nebulization

Group Type ACTIVE_COMPARATOR

technetium-99m - Diethylenetriaminepentaacetic acid

Intervention Type DRUG

Vibrating-mesh nebulizer

Intervention Type DEVICE

Gamma scintigraphy

Intervention Type OTHER

Preoperative spirometry

Intervention Type OTHER

Nebulization during volume assist control mode

Patients ventilated in volume assist control mode during nebulization

Group Type ACTIVE_COMPARATOR

technetium-99m - Diethylenetriaminepentaacetic acid

Intervention Type DRUG

Vibrating-mesh nebulizer

Intervention Type DEVICE

Gamma scintigraphy

Intervention Type OTHER

Preoperative spirometry

Intervention Type OTHER

Interventions

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technetium-99m - Diethylenetriaminepentaacetic acid

Intervention Type DRUG

Vibrating-mesh nebulizer

Intervention Type DEVICE

Gamma scintigraphy

Intervention Type OTHER

Preoperative spirometry

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Invasive mechanical ventilation
* Healthy lungs

Exclusion Criteria

* Change of ventilation mode during nebulization
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre-François Laterre

Role: STUDY_CHAIR

Head of Intensive Care Unit, Cliniques Universitaires Saint-Luc

Locations

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Cliniques Universitaires Saint-Luc

Brussels, , Belgium

Site Status

Countries

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Belgium

References

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Dugernier J, Reychler G, Wittebole X, Roeseler J, Depoortere V, Sottiaux T, Michotte JB, Vanbever R, Dugernier T, Goffette P, Docquier MA, Raftopoulos C, Hantson P, Jamar F, Laterre PF. Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study. Ann Intensive Care. 2016 Dec;6(1):73. doi: 10.1186/s13613-016-0169-x. Epub 2016 Jul 22.

Reference Type DERIVED
PMID: 27447788 (View on PubMed)

Other Identifiers

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AeroVent-01

Identifier Type: -

Identifier Source: org_study_id