Soccer and Health: Diet and Exercise on Type 2 Diabetes Mellitus

NCT ID: NCT02554643

Last Updated: 2015-09-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2015-07-31

Brief Summary

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The present study aims to evaluate the impact of a soccer training program lasting 12 weeks in patients with type 2 diabetes mellitus. 60 sedentary adults and elderly patients with type 2 diabetes mellitus (age: 50-75 y), with a BMI \> 25kg/m2 and \> 29kg/m2, respectively, from the Hospital of the Medical Faculty of São Paulo University will participate in this study. They will be randomly divided in 3 groups (soccer, running and control). All patients will undergo the following assessments: anthropometric, dietary, physical performance, inflammatory, metabolic and hormonal parameters such as gene expression, bone markers and predictors of cardiovascular disease. In addition the investigators aim to evaluate the body composition of these patients by DXA, and muscle and visceral lipids content by proton spectroscopic MRI.

Detailed Description

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The present study aims to evaluate the regular soccer practice on cardiorespiratory fitness, body composition, bone health and metabolic and hormonal variables, and compare it with other types of classic aerobic training, such as running, for example .

Soccer is a high popularity team sport, with more than 400 million active practitioners in the world, and due to various motivational and social factors of this activity we can consider it as a great tool potential in promoting the health of sedentary individuals, but football fans. Thus, we believe that the combined use of exercises that make up the soccer training, such as running, walking, sprints, acceleration, deceleration, jumps, side court, dribbling, etc., can result in significant adaptive changes in the physiological system, contributing improvements in cardiovascular function, bone mineralization in muscle strength, physical performance and metabolism of lipids and glucose.

Therefore we aimed to investigate in patients with diabetes mellitus type 2 the impact of a soccer training program with 12 weeks:

* body composition, by examining DXA, assessing the content of lean mass and fat mass;
* the concentration of muscle and visceral fat by means of nuclear magnetic resonance spectroscopy;
* the bone markers for the quantification of osteocalcin hormone, carboxy terminal telopeptides (CTX), propeptide amino-terminal of procollagen type I (P1NP), parathyroid hormone (PTH) and 25-hydroxy vitamin D, growth factor insulin-like-1 free ( IGF1-free);

As a secondary objective, we intend to evaluate the impact of soccer training and classic aerobic exercise on metabolic and hormonal variables of type 2 diabetic patients:

* the parameters of cardiovascular disease, for investigating blood pressure and quantification of lipid fractions (total cholesterol and fractions, triglycerides) and C-reactive protein;
* physical performance, evaluating the physical capacity by examining ergospirometry;
* and the metabolic variables, enzymatic and hormonal following: blood glucose, glycated hemoglobin (HbA1c), tolerance test oral glucose (OGTT), blood lactate, free fatty acids, blood count, insulin, proinsulin, leptin, adiponectin, and enzymes AST, ALT, CK and DHL.

Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Diet & Soccer

Nutritional Intervention (Diet) once a week, during 12 weeks

\+ Soccer training, 3 times a week, during 12 weeks

Group Type EXPERIMENTAL

Diet

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks

Soccer

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks + Soccer training, 3 x week, during 12 weeks

Diet & Running

Nutritional Intervention (Diet) once a week, during 12 weeks

\+ Running training, 3 times a week, during 12 weeks

Group Type EXPERIMENTAL

Diet

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks

Running

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks + Running training, 3 x week, during 12 weeks

Diet

Nutritional Intervention (Diet) once a week, during 12 weeks

Group Type ACTIVE_COMPARATOR

Soccer

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks + Soccer training, 3 x week, during 12 weeks

Running

Intervention Type OTHER

Nutrition intervention, once a week during 12 weeks + Running training, 3 x week, during 12 weeks

Interventions

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Diet

Nutrition intervention, once a week during 12 weeks

Intervention Type OTHER

Soccer

Nutrition intervention, once a week during 12 weeks + Soccer training, 3 x week, during 12 weeks

Intervention Type OTHER

Running

Nutrition intervention, once a week during 12 weeks + Running training, 3 x week, during 12 weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Inclusion Criteria: patients with diabetes type 2 diabetes, up to 15 years in duration, HbA1c from 6.5 to 11.0%, with none administration of insulin.

Exclusion Criteria: patients with BMI lower (\<) than 25 kg/m2 and higher (\>) than 48 kg/m2, blood pressure \> 160/100 mm Hg, fasting triglyceride levels of\> 500 mg / dL, proteinuria\> 100 mg / dL, serum creatinine\> 1.5 mg / dL, liver complications, neuropathy or advanced retinopathy, macroangiopathy, diabetic foot, or any other serious health condition that impairs their adherence to the training protocol satisfactorily.
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sao Paulo General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maysa Sousa

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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Laboratory of Medical Investigation - LIM 18, University of São Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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Exercise on Type 2 Diabetes

Identifier Type: -

Identifier Source: org_study_id

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