Adjunctive Role of PRF After Free Gingival Graft Harvesting

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Free gingival grafts are important to increase zone of attached gingiva and root coverage. This case series reveals role of platelet-rich fibrin (PRF) as adjunctive therapy in palatal wound healing. The superior healing observed at the PRF membrane sites supports its use in accelerating soft-tissue healing. PRF membrane as a palatal bandage is an efficacious approach to protect the raw wound area of a palatal donor site to reduce healing time and patient discomfort.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

PRF for Accelerating Palatal Healing

NCT02712242

Gingival Recession

COMPLETED NA

Effects of Platelet Concentrates on Palatal Wound Healing

NCT04097509

Wound Heal Platelets; Defect Periodontal Inflammation +1 more

COMPLETED NA

Effect of PRF Palatal Bandage on Pain Scores and Wound Healing After Free Gingival Graft

NCT02797899

Pain Wound Healing

COMPLETED NA

Platelet Rich Fibrin in the Treatment of Palatal Wounds

NCT02438046

Gingival Recession

UNKNOWN PHASE4

Platelet Rich Fibrin in the Treatment of Full Thickness Palatal Wounds

NCT04043039

Gingival Recession

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Introduction:

Free gingival grafts are one of the common treatment modalities used to increase the zone of keratinized tissue (KT) around implants or prior to ridge augmentation and root coverage. The palatal donor sites had many complications as pain, discomfort and healing by secondary intention. Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors fasten the healing and decrease the pain.

Materials and methods:

Ten patients requiring augmentation of KT participated in this case series. The palatal donor sites of 7 of these patients were covered with PRF membranes with a new suturing technique without palatal stent, the other 3 had palatal stent. Palatal tissue will examined clinically after 3, 7, 10 and 14 days. Considerably very fast healing with 0 pain score was observed during one week in the group with PRF.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Platelets Rich Fibrin, Palatal Donor Tissue

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PRF

Platelets Rich Fibrin

Group Type ACTIVE_COMPARATOR

Platelets Rich Fibrin in healing of palatal donor tissue

Intervention Type BIOLOGICAL

Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors as PDGF, IGF, TGF which had a role in hemostasis fasten the healing and decrease the pain.

palatal stent

Palatal stent

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

the other group is a control group, had no biologic in the palatal wound, only palatal stent

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Platelets Rich Fibrin in healing of palatal donor tissue

Platelets Rich Fibrin (PRF) is a second generation of platelets concentrate full of growth factors as PDGF, IGF, TGF which had a role in hemostasis fasten the healing and decrease the pain.

Intervention Type BIOLOGICAL