Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
68 participants
INTERVENTIONAL
2025-07-12
2025-12-10
Brief Summary
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The study examines three patient groups treated at the periodontology departments of Çukurova and Biruni University: one with gelatin sponge (control), one with chitosan, and one with chitosan infused with i-PRF. Parameters such as pain (VAS), bleeding, burning sensation, dietary changes, epithelialization (PEHI score), and color match were assessed over a 2-month follow-up.
The findings are expected to provide insights into whether i-PRF-enhanced chitosan offers superior healing outcomes and greater patient comfort compared to conventional methods.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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control
control group
free gingival graft + gelatin sponge
Free gingival graft surgery and application of gelatin sponge to the palatal wound
chitosan
free gingival graft + chitosan
free gingival graft surgery and application of chitosan to the palatal wound
chitosan-iprf
free gingival graft + chitosan and i-PRF
free gingival graft surgery and application of chitosan and i-PRF to the palatal wound
Interventions
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free gingival graft + gelatin sponge
Free gingival graft surgery and application of gelatin sponge to the palatal wound
free gingival graft + chitosan
free gingival graft surgery and application of chitosan to the palatal wound
free gingival graft + chitosan and i-PRF
free gingival graft surgery and application of chitosan and i-PRF to the palatal wound
Eligibility Criteria
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Inclusion Criteria
* Having good oral hygiene (plaque accumulation \<20%)
* Requiring a free gingival graft (FGG) procedure in an area with insufficient keratinized gingiva width (\<2 mm)
Exclusion Criteria
* Uncontrolled diabetes (HbA1c \> 7),
* Being pregnant or breastfeeding,
* Autoimmune and/or inflammatory diseases of the oral cavity,
* Active periodontal disease,
* Smokers (≥ 10 cigarettes per day)
18 Years
65 Years
ALL
No
Sponsors
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Cukurova University
OTHER
Biruni University
OTHER
Responsible Party
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Burcu KARADUMAN
Prof.
Locations
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Cukurova University
Adana, , Turkey (Türkiye)
Biruni University
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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Chitosan-iPRF
Identifier Type: -
Identifier Source: org_study_id
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