Effect of Cyanoacrylate and Concentrated Growth Factor on Palatal Donor Site
NCT ID: NCT06459947
Last Updated: 2025-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2024-03-02
2025-07-28
Brief Summary
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Detailed Description
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Periodontal dressings, acrylic stents, hemostatic agents, surgical sponges, platelet concentrates, low-level laser therapy, photobiomodulation, cyanoacrylate tissue adhesives and hyaluronic acid are some of the methods used for donor site management or to accelerate healing.
Cyanoacrylate adhesives form an adhesive film through rapid polymerization triggered by the hydroxyl groups on the surfaces to which they are applied. They have both bacteriostatic and hemostatic properties.
In recent years, it has been observed that the use of platelet concentrates such as Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF) and autogenous products such as CGF (concentrated growth factor) in periodontal treatments has increased.
CGF is obtained by centrifuging blood in four different cycles and times. This product contains a relatively intact fibrin clot containing platelets, leukocytes, various growth factors and cytokines. CGF can be applied as a carrier of growth factors and/or a barrier membrane to aid tissue regeneration and wound healing in clinical applications.
The aim of this planned randomized controlled clinical study is to evaluate the morbidity of the palatal donor area after FGG operations. In this study, wound healing and pain levels in the palatal region will be evaluated after cyanoacrylate and CGF applications.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Group 1 (Control group)
After FGG is taken from the palatal area, the sponge is placed in the wound area.
Free gingival graft procedure
The palatal area is anesthetized using local anesthesia. The free gingival graft (FGG) is taken from the donor site with a scalpel.
Group 2 (Cyanoacrylate group)
After the FGG is taken from the palatal area, a cyanoacrylate tissue adhesive is placed in the wound area.
Free gingival graft procedure
The palatal area is anesthetized using local anesthesia. The free gingival graft (FGG) is taken from the donor site with a scalpel.
Group 3 (Concentrated Growth Factor group)
After the FGG is taken from the palatal area, concentrated growth factor (CGF) group is placed in the wound area. CGF is obtained by centrifuging blood in four different cycles and times.
Free gingival graft procedure
The palatal area is anesthetized using local anesthesia. The free gingival graft (FGG) is taken from the donor site with a scalpel.
Interventions
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Free gingival graft procedure
The palatal area is anesthetized using local anesthesia. The free gingival graft (FGG) is taken from the donor site with a scalpel.
Eligibility Criteria
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Inclusion Criteria
* not had periodontal surgery in the last 6 months
Exclusion Criteria
* allergic to medication
* high anxiety (using modified dental anxiety scale)
18 Years
55 Years
ALL
Yes
Sponsors
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Yuzuncu Yil University
OTHER
Responsible Party
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Dicle Altındal
DDS, Assistant Professor
Principal Investigators
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Dicle Altindal, DDS
Role: PRINCIPAL_INVESTIGATOR
Yuzuncu Yil University
Elif Tore Sari, PhD
Role: STUDY_CHAIR
Yuzuncu Yil University
Nazli Zeynep Alpaslan, PhD
Role: STUDY_CHAIR
Yuzuncu Yil University
Locations
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Van Yuzuncu Yil University
Van, , Turkey (Türkiye)
Countries
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References
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Lektemur Alpan A, Torumtay Cin G. PRF improves wound healing and postoperative discomfort after harvesting subepithelial connective tissue graft from palate: a randomized controlled trial. Clin Oral Investig. 2020 Jan;24(1):425-436. doi: 10.1007/s00784-019-02934-9. Epub 2019 May 18.
Verissimo AH, Ribeiro AKC, Martins ARLA, Gurgel BCV, Lins RDAU. Comparative analysis of the hemostatic, analgesic and healing effects of cyanoacrylate on free gingival graft surgical wounds in donor and recipient areas: a systematic review. J Mater Sci Mater Med. 2021 Aug 18;32(9):98. doi: 10.1007/s10856-021-06573-z.
Other Identifiers
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28.02.2024/07
Identifier Type: -
Identifier Source: org_study_id
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