Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions
NCT ID: NCT02018120
Last Updated: 2013-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
26 participants
INTERVENTIONAL
2012-05-31
2013-08-31
Brief Summary
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Detailed Description
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Primary outcome variables were percentage of complete root coverage and mean root coverage percentages at 6 months follow up. The secondary outcome variables include keratinized tissue and gingival thickness gain.
Sample size has been estimated as 13 in each treatment arm. All recessions are treated with modified coronally advanced flap. On test sites PRF membrane and on control sites connective tissue grafts will be placed under modified coronally advanced flaps. Random allocation of the treatment sites to test and control groups were performed using a computer software designed for randomization.
Clinical parameters such as gingival index, plaque index, keratinized tissue width, gingival recession depth and width were measured at 1, 3 and 6 months. Probing pocket depth, clinical attachment level, gingival thickness and gingival recession area were measure at baseline and 6 months. All gingival recession-related parameters such as recession height, recession width and recession area and keratinized tissue width along with mean root coverage and complete root coverage were assessed on standardized clinical photographs using an image analysis software.
Clinical photographs were obtained at baseline and 1, 3 and 6 months after surgical intervention. 4 mm length wire was placed on gingiva to check reproducibility and to obtain standardized pictures.
Gingival tissue thickness were measured with an #15 endodontic reamer attached to rubber stopper inserted perpendicularly into the gingival tissue 2 mm below the gingival margin; thickness of the reamer will be measured with a digital caliper.
Mean root coverage percentage was calculated as percentage of covered root surface area at 6 months.
Follow up of subjects was 6 months.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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connective tissue graft
connective tissue graft harvested from palatum of subjects and placed under modified coronally advanced flap
connective tissue graft
Platelet rich fibrin
Autogenous platelet rich fibrin was obtained from subjects own blood samples after centrifugation. Platelet rich fibrin membranes were placed under modified coronally advanced flaps.
platelet rich fibrin
Interventions
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connective tissue graft
platelet rich fibrin
Eligibility Criteria
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Inclusion Criteria
* Identifiable CEJ on all teeth
* Age ≥ 18
* Presence of tooth vitality and absence of restorations and superficial caries in the treatment area
* No past surgical treatment history of affected area.
* Gingival thickness ≥ 0,8 mm for recession areas.
* Sufficient palatal donor tissue for connective tissue harvesting.
Exclusion Criteria
* Pregnancy or lactation
* Systematic diseases that may affect outcomes of periodontal therapy
* Self-reported antibiotic medication within three months
* Occlusal trauma in treatment site
18 Years
ALL
No
Sponsors
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Ege University
OTHER
Responsible Party
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Asude Merve Polat
PhD
Principal Investigators
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Gül Atilla, Professor
Role: STUDY_DIRECTOR
Ege University School of Dentistry
Locations
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Ege University School of Dentistry Department of Periodontology
Izmir, Bornova, Turkey (Türkiye)
Countries
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Other Identifiers
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2012-Dis-004
Identifier Type: -
Identifier Source: org_study_id