Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-28

Study Completion Date

2014-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG. 40 patients were surgically treated either with CAF+CTG+PRF (test group) or CAF+CTG (control group). Clinical parameters of plaque index (PI), gingival index (GI), vertical recession (VR), probing depth (PD), attachment level (AL), keratinized tissue width (KTW), horizontal recession (HR), MGJ localization (L-MGJ), tissue thickness (TT) were recorded at baseline, 3 months (PS1) and 6 months (PS2) post-surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions

NCT02335866

Gingival Recessions

COMPLETED EARLY_PHASE1

Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects.

NCT04032405

Gingival Recession

COMPLETED NA

Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions

NCT02018120

Gingival Recession

COMPLETED NA

Effect of Dose-dependent Platelet Rich Fibrin(PRF)

NCT02882464

Gingival Recession

COMPLETED NA

Platelet-Rich Fibrin Prepared With Titanium in the Treatment of Multiple Gingival Recessions

NCT05270941

Gingival Recession

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Given the encouraging effects of platelet-rich fibrin (PRF) in healing and regeneration, it has been hypothesized that PRF might develop the outcomes obtained with coronally advanced flap (CAF)+connective tissue graft(CTG). Therefore, it was aimed to evaluate the effectiveness of CAF + CTG + PRF in Miller Class I and II recession defect treatment by comparing the outcomes with CAF + CTG in a preliminary, controlled, randomized clinical trial (RCT) with a 6-month follow-up. The study was conducted with 40 patients randomly grouped in half shares into indicated study groups. After phase I therapy, clinical variables including plaque index (PI), gingival index (GI), vertical recession (VR), probing depth (PD), attachment level (AL), keratinized tissue width (KTW), horizontal recession (HR), MGJ localization (L-MGJ), tissue thickness (TT) were recorded. The surgical sites were prepared by using sulcular and adjacent vertical incisions and CTGs were harvested from the palatal regions. Different from CAF+CTG group, PRF was prepared by obtaining 10 ml venous blood, centrifugation and extraction of the gel containing highly concentrated platelet cells in CAF+CTG+PRF patients. Then the gel was placed over the exposed root surface in the same group. The CAF was primarily closed and postoperative instructions were given. After suture removal at second postoperative week, the patients were followed-up by monthly recall visits. Same periodontal clinical variables were recorded 3 and 6 months after surgery.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Gingival Recession

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PRF+CAF+CTG

platelet-rich fibrin + coronally advanced flap + connective tissue graft

Group Type EXPERIMENTAL

platelet-rich fibrin

Intervention Type BIOLOGICAL

autologous platelet-rich fibrin was isolated from venous blood of each patient by defined centrifugation methods

connective tissue graft

Intervention Type PROCEDURE

connective tissue graft was harvested from the palatal region of each patient by single incision method

coronally advanced flap

Intervention Type PROCEDURE

buccal gingival flap was raised by sharp-blunt-sharp dissection and positioned coronally to cover connective tissue graft (and platelet-rich fibrin gel)

CAF+CTG

coronally advanced flap + connective tissue graft

Group Type ACTIVE_COMPARATOR

connective tissue graft

Intervention Type PROCEDURE

connective tissue graft was harvested from the palatal region of each patient by single incision method

coronally advanced flap

Intervention Type PROCEDURE

buccal gingival flap was raised by sharp-blunt-sharp dissection and positioned coronally to cover connective tissue graft (and platelet-rich fibrin gel)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.