Coherence Between Brain Cortical Function and Neurocognitive Performance During Changed Gravity Conditions

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Alongside a well-known physiological deconditioning, such as a decrease in muscle mass or bone demineralization, extended stays in weightlessness also cause cognitive dysfunction. However, the studies on this subject during space missions short or long term could not determine how these cognitive dysfunction resulted from a direct effect of weightlessness or a stress-related effect.

Analysis of electro-encephalography (EEG) using a standardized mapping method is used to study the changes of operation of the cerebral cortex as the near infrared spectroscopy (NIRS) is a reflection of changes in the cerebral hemodynamics. Their combined use is a relatively simple and economical method for studying brain changes in an environment where the normal brain imaging techniques can not be used.

The main objective of this experiment is to evaluate the alterations in brain cortical activity and brain oxygenation level induced by micro- and hypergravity conditions.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Parabolic Flight Induced Neuroplasticity Studied With Advanced Magnetic Resonance Imaging Methods

NCT02517216

Healthy

UNKNOWN NA

THE INFLUENCE OF GRAVITY

NCT03298139

Healthy Volunteers

UNKNOWN NA

Body-environment Relationship Related Modified Gravity

NCT05531162

Body Schema

COMPLETED NA

Influence of Gravity on Dexterity, Hand-eye Coordination and Perception of Orientation and Distances

NCT02563249

Healthy Volunteers

UNKNOWN NA

Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis

NCT04856410

Brain Structure Cognitive Performance

ENROLLING_BY_INVITATION NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

EEG and NIRS measurements

Group Type OTHER

Parabolic flight

Intervention Type OTHER

EEG measurement

Intervention Type OTHER

Electro cortical power in alpha frequency ranges (EEG-LORETA)

NIRS measurements

Intervention Type OTHER

Brain tissue oxygenation ( oxy- or deoxygenated hemoglobin values) - NIRS

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Parabolic flight

Intervention Type OTHER

EEG measurement

Electro cortical power in alpha frequency ranges (EEG-LORETA)

Intervention Type OTHER

NIRS measurements

Brain tissue oxygenation ( oxy- or deoxygenated hemoglobin values) - NIRS

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* healthy volunteers (men or women),
* aged from 18 to 65,
* affiliated to a Social Security system and, for non-French resident, holding an European Health Insurance Card (EHIC)
* who accept to take part in the study,
* who have given their written stated consent,
* who already participated in parabolic flights (even in the same campaign)
* All subjects will pass a medical examination similar to a standard aviation medical examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There will be no additional test performed for subject selection.

Exclusion Criteria

* Persons who took part in a previous biomedical research protocol, of which exclusion period is not terminated,
* Persons with prior serious injuries to their head
* Persons who take any medication or drugs influencing their central nervous system or cognitive performance
* Pregnant women.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes