Pulse Pressure Variation Measured During Valsalva Maneuver to Predict Fluid Responsiveness Under Open-chest Condition

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

55 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2015-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Pulse pressure variation (PPV) is a well-known dynamic preload indicator to predict fluid responsiveness. However, its usefulness in open-chest conditions has been equivocal. The investigators evaluated whether PPV measured during Valsalva maneuver can predict fluid responsiveness after sternotomy.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy

NCT02653469

Gynecologic Neoplasms Abdominal Neoplasms

COMPLETED

Pulse Pressure Variations as Index of Preload Dependency During Thoracic Surgery

NCT01329146

Fluid Response

COMPLETED

Pulse Pressure Variation in Spontaneously Breathing Patients

NCT01402934

Pulse Pressure Variation Spontaneously Breathing

COMPLETED NA

An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients

NCT01681758

Cardiac Surgery

COMPLETED PHASE2

Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients

NCT07189026

Cardiac Surgery Mechanical Ventilation After Surgery

ACTIVE_NOT_RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiac Surgical Procedures Thoracic Surgical Procedures Sternotomy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Valsalva maneuver

This is an observational study and as a diagnostic intervention, subjects in the study would receive valsalva maneuver. Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration. The investigators perform this procedure to every patients and do not assign this intervention to the subjects of the study.

Valsalva maneuver

Intervention Type PROCEDURE

Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration.

Fluid loading

Intervention Type OTHER

We record the cardiac index values before and after volume expansion with 6ml/kg of balanced crystalloid

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Valsalva maneuver

Valsalva maneuver was performed after sternotomy with the constant airway pressure of 30cmH2O for 2 breaths duration.

Intervention Type PROCEDURE

Fluid loading

We record the cardiac index values before and after volume expansion with 6ml/kg of balanced crystalloid

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lung recruitment maneuver Balanced crystalloid infusion

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

\- Adult patients undergoing elective off-pump coronary arterial bypass grafting

Exclusion Criteria

* Preoperative LV EF \<= 35%
* Moderate or severe valvular heart disease
* Cardiac arrhythmia
* Intracardiac shunt
* Severe renal or liver disease
* Moderate to severe pulmonary hypertension (mean PAP \> 35 mmHg)
* Patients with bullous lung disease or combined pneumothorax

Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No