OLA to Lowest DP in Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-10

Study Completion Date

2019-02-28

Brief Summary

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This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.

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Detailed Description

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Conditions

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Lung Collapse

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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DP-PEEP

recruitment maneuver + individualized PEEP

Group Type EXPERIMENTAL

DP-PEEP

Intervention Type PROCEDURE

PEEP titration trial for the lowest DP after the alveolar recruitment maneuver

RM-5

recruitment maneuver + fixed standard PEEP

Group Type ACTIVE_COMPARATOR

RM-5

Intervention Type PROCEDURE

Fixed standard PEEP after the alveolar recruitment maneuver

Interventions

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DP-PEEP

PEEP titration trial for the lowest DP after the alveolar recruitment maneuver

Intervention Type PROCEDURE

RM-5

Fixed standard PEEP after the alveolar recruitment maneuver

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)

Exclusion Criteria

* i) age \<18yr or \>80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index \>35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No