The Effects of Spinal Manipulation on Thigh Muscle Strength
NCT ID: NCT02407418
Last Updated: 2015-04-03
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
21 participants
Study Classification
INTERVENTIONAL
Study Start Date
2012-04-30
Study Completion Date
2012-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The purpose of this study was to investigate the effects of chiropractic low back adjustments on thigh muscle strength. Force production was measured during different types of muscle contractions with a device called an isokinetic dynamometer. The study included 21 college-aged subjects who did not have any pain and had never received chiropractic treatment with spinal manipulation. During two separate sessions, subjects' thigh muscle forces were recorded while performing maximal muscle contractions on the isokinetic dynamometer. Baseline measurements of muscle force were acquired before either treatment form of spinal manipulation or a sham spinal manipulation, followed by identical muscle force measurements within five and twenty minutes post-treatment.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Effect of Spinal Manipulation on Hip Extension Strength and Jump Height
NCT05689723
Weakness, Muscle
UNKNOWN
NA
Effects of a Thoracic Manipulation on Hip Adductor, Extensor, and Latissimus Dorsi Force in Those With Adductor Weakness
NCT06534931
Muscle Weakness
COMPLETED
NA
The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment
NCT02848456
Subluxation of Joint of Lumbar Spine
COMPLETED
NA
Comparison of Activator Manipulation Versus Manual Side Posture Manipulation in Patients With Low Back Pain
NCT00497861
Back Pain
COMPLETED
NA
Chiropractic Distraction Spinal Manipulation- Lumbar Stenosis Study
NCT03863769
Spinal Stenosis Lumbar
COMPLETED
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Spinal manipulation is a therapeutic procedure employed by various healthcare practitioners for alleviating acute and chronic musculoskeletal complaints. This form of treatment is also delivered to enhance the performance and augment the rehabilitation of athletes. However, despite research findings alleging the strength-modulating effects of spinal manipulation alongside numerous professional athletes' positive anecdotal claims concerning its results, the physiological processes to explain its effects remain largely unexplained. Therefore, the purpose of this work was to investigate the effects of spinal manipulation in a college-aged sample population.
This study examined the effect of spinal manipulation delivered to the lumbosacral region on concentric force production of the knee extensors and flexors. A randomized, controlled, single-blind repeated measures design was utilized with 21 subjects. Isometric and isokinetic peak torques (Nm) were recorded during two separate session while subjects performed maximal voluntary contractions post-treatment of either spinal manipulation or a sham manipulation.
This study examined the effect of spinal manipulation delivered to the lumbosacral region on concentric force production of the knee extensors and flexors. A randomized, controlled, single-blind repeated measures design was utilized with 21 subjects. Isometric and isokinetic peak torques (Nm) were recorded during two separate session while subjects performed maximal voluntary contractions post-treatment of either spinal manipulation or a sham manipulation.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Subluxation of Joint of Lumbar Spine
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
CROSSOVER
Primary Study Purpose
BASIC_SCIENCE
Blinding Strategy
SINGLE
Participants
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Spinal Manipulation
In a repeated measures, crossover design, all subjects received spinal manipulation during the second or third session. The selection of spinal manipulation or sham was randomized.
Group Type
ACTIVE_COMPARATOR
Spinal Manipulation
Intervention Type
OTHER
Side-posture, high-velocity low-amplitude spinal manipulation targeting the lumbar spine and sacroiliac joints
Sham Manipulation
In a repeated measures, crossover design, all subjects received the sham manipulation during the second or third session. The selection of spinal manipulation or sham was randomized.
Group Type
SHAM_COMPARATOR
Sham Manipulation
Intervention Type
OTHER
A simulated lumbar spine manipulation in which no vertebral contact was made
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Spinal Manipulation
Side-posture, high-velocity low-amplitude spinal manipulation targeting the lumbar spine and sacroiliac joints
Intervention Type
OTHER
Sham Manipulation
A simulated lumbar spine manipulation in which no vertebral contact was made
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Between the ages of 20 to 35 years
* Asymptomatic with regard to low back, pelvic or lower extremity pain
* Asymptomatic with regard to low back, pelvic or lower extremity pain
Exclusion Criteria
* Previously received spinal manipulation from a chiropractor or other health care provider
* Contraindications to lumbar spine manipulation (such as fractures, lumbar disc herniation, abdominal aortic aneurysm or cauda equina syndrome)
* Contraindications to lumbar spine manipulation (such as fractures, lumbar disc herniation, abdominal aortic aneurysm or cauda equina syndrome)
Minimum Eligible Age
20 Years
Maximum Eligible Age
35 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Grant Sanders
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Grant Sanders
Sponsor/Investigator
Responsibility Role
SPONSOR_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Grant D Sanders, D.C.
Role: PRINCIPAL_INVESTIGATOR
University of Kentucky
References
Explore related publications, articles, or registry entries linked to this study.
Hurwitz EL. Epidemiology: spinal manipulation utilization. J Electromyogr Kinesiol. 2012 Oct;22(5):648-54. doi: 10.1016/j.jelekin.2012.01.006. Epub 2012 Jan 29.
Reference Type
BACKGROUND
Pickar JG. Neurophysiological effects of spinal manipulation. Spine J. 2002 Sep-Oct;2(5):357-71. doi: 10.1016/s1529-9430(02)00400-x.
Reference Type
BACKGROUND
Miners AL. Chiropractic treatment and the enhancement of sport performance: a narrative literature review. J Can Chiropr Assoc. 2010 Dec;54(4):210-21.
Reference Type
BACKGROUND
Grindstaff TL, Hertel J, Beazell JR, Magrum EM, Ingersoll CD. Effects of lumbopelvic joint manipulation on quadriceps activation and strength in healthy individuals. Man Ther. 2009 Aug;14(4):415-20. doi: 10.1016/j.math.2008.06.005. Epub 2008 Sep 20.
Reference Type
BACKGROUND
Hillermann B, Gomes AN, Korporaal C, Jackson D. A pilot study comparing the effects of spinal manipulative therapy with those of extra-spinal manipulative therapy on quadriceps muscle strength. J Manipulative Physiol Ther. 2006 Feb;29(2):145-9. doi: 10.1016/j.jmpt.2005.12.003.
Reference Type
BACKGROUND
Suter E, McMorland G, Herzog W, Bray R. Conservative lower back treatment reduces inhibition in knee-extensor muscles: a randomized controlled trial. J Manipulative Physiol Ther. 2000 Feb;23(2):76-80.
Reference Type
BACKGROUND
Suter E, McMorland G, Herzog W, Bray R. Decrease in quadriceps inhibition after sacroiliac joint manipulation in patients with anterior knee pain. J Manipulative Physiol Ther. 1999 Mar-Apr;22(3):149-53. doi: 10.1016/S0161-4754(99)70128-4.
Reference Type
BACKGROUND
Botelho MB, Andrade BB. Effect of cervical spine manipulative therapy on judo athletes' grip strength. J Manipulative Physiol Ther. 2012 Jan;35(1):38-44. doi: 10.1016/j.jmpt.2011.09.005. Epub 2011 Nov 10.
Reference Type
BACKGROUND
Fernandez-Carnero J, Fernandez-de-las-Penas C, Cleland JA. Immediate hypoalgesic and motor effects after a single cervical spine manipulation in subjects with lateral epicondylalgia. J Manipulative Physiol Ther. 2008 Nov-Dec;31(9):675-81. doi: 10.1016/j.jmpt.2008.10.005.
Reference Type
BACKGROUND
Paungmali A, Vicenzino B, Smith M. Hypoalgesia induced by elbow manipulation in lateral epicondylalgia does not exhibit tolerance. J Pain. 2003 Oct;4(8):448-54. doi: 10.1067/s1526-5900(03)00731-4.
Reference Type
BACKGROUND
Abbott JH, Patla CE, Jensen RH. The initial effects of an elbow mobilization with movement technique on grip strength in subjects with lateral epicondylalgia. Man Ther. 2001 Aug;6(3):163-9. doi: 10.1054/math.2001.0408.
Reference Type
BACKGROUND
Giggey K, Tepe R. A pilot study to determine the effects of a supine sacroiliac orthopedic blocking procedure on cervical spine extensor isometric strength. J Chiropr Med. 2009 Jun;8(2):56-61. doi: 10.1016/j.jcm.2008.11.002.
Reference Type
BACKGROUND
Keller TS, Colloca CJ. Mechanical force spinal manipulation increases trunk muscle strength assessed by electromyography: a comparative clinical trial. J Manipulative Physiol Ther. 2000 Nov-Dec;23(9):585-95. doi: 10.1067/mmt.2000.110947.
Reference Type
BACKGROUND
Suter E, McMorland G. Decrease in elbow flexor inhibition after cervical spine manipulation in patients with chronic neck pain. Clin Biomech (Bristol). 2002 Aug;17(7):541-4. doi: 10.1016/s0268-0033(02)00025-6.
Reference Type
BACKGROUND
Wang SS, Meadows J. Immediate and carryover changes of C5-6 joint mobilization on shoulder external rotator muscle strength. J Manipulative Physiol Ther. 2010 Feb;33(2):102-8. doi: 10.1016/j.jmpt.2009.12.006.
Reference Type
BACKGROUND
Panton LB, Figueroa A, Kingsley JD, Hornbuckle L, Wilson J, St John N, Abood D, Mathis R, VanTassel J, McMillan V. Effects of resistance training and chiropractic treatment in women with fibromyalgia. J Altern Complement Med. 2009 Mar;15(3):321-8. doi: 10.1089/acm.2008.0132.
Reference Type
BACKGROUND
Morningstar MW. Strength gains through lumbar lordosis restoration. J Chiropr Med. 2003 Autumn;2(4):137-41. doi: 10.1016/S0899-3467(07)60077-9.
Reference Type
BACKGROUND
de Almeida BS, Sabatino JH, Giraldo PC. Effects of high-velocity, low-amplitude spinal manipulation on strength and the basal tonus of female pelvic floor muscles. J Manipulative Physiol Ther. 2010 Feb;33(2):109-16. doi: 10.1016/j.jmpt.2009.12.007.
Reference Type
BACKGROUND
Chilibeck PD, Cornish SM, Schulte A, Jantz N, Magnus CR, Schwanbeck S, Juurlink BH. The effect of spinal manipulation on imbalances in leg strength. J Can Chiropr Assoc. 2011 Sep;55(3):183-92.
Reference Type
BACKGROUND
Knapik JJ, Wright JE, Mawdsley RH, Braun J. Isometric, isotonic, and isokinetic torque variations in four muscle groups through a range of joint motion. Phys Ther. 1983 Jun;63(6):938-47. doi: 10.1093/ptj/63.6.938.
Reference Type
BACKGROUND
Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.
Reference Type
BACKGROUND
Sole G, Hamren J, Milosavljevic S, Nicholson H, Sullivan SJ. Test-retest reliability of isokinetic knee extension and flexion. Arch Phys Med Rehabil. 2007 May;88(5):626-31. doi: 10.1016/j.apmr.2007.02.006.
Reference Type
BACKGROUND
Drouin JM, Valovich-mcLeod TC, Shultz SJ, Gansneder BM, Perrin DH. Reliability and validity of the Biodex system 3 pro isokinetic dynamometer velocity, torque and position measurements. Eur J Appl Physiol. 2004 Jan;91(1):22-9. doi: 10.1007/s00421-003-0933-0. Epub 2003 Sep 24.
Reference Type
BACKGROUND
Todd G, Gorman RB, Gandevia SC. Measurement and reproducibility of strength and voluntary activation of lower-limb muscles. Muscle Nerve. 2004 Jun;29(6):834-42. doi: 10.1002/mus.20027.
Reference Type
BACKGROUND
Akebi T, Saeki S, Hieda H, Goto H. Factors affecting the variability of the torque curves at isokinetic trunk strength testing. Arch Phys Med Rehabil. 1998 Jan;79(1):33-5. doi: 10.1016/s0003-9993(98)90204-0.
Reference Type
BACKGROUND
Frost LR, Gerling ME, Markic JL, Brown SH. Exploring the effect of repeated-day familiarization on the ability to generate reliable maximum voluntary muscle activation. J Electromyogr Kinesiol. 2012 Dec;22(6):886-92. doi: 10.1016/j.jelekin.2012.05.005. Epub 2012 Jun 20.
Reference Type
BACKGROUND
Pickar JG, Bolton PS. Spinal manipulative therapy and somatosensory activation. J Electromyogr Kinesiol. 2012 Oct;22(5):785-94. doi: 10.1016/j.jelekin.2012.01.015. Epub 2012 Feb 19.
Reference Type
BACKGROUND
Haavik H, Murphy B. The role of spinal manipulation in addressing disordered sensorimotor integration and altered motor control. J Electromyogr Kinesiol. 2012 Oct;22(5):768-76. doi: 10.1016/j.jelekin.2012.02.012. Epub 2012 Apr 6.
Reference Type
BACKGROUND
Korr IM. Somatic dysfunction, osteopathic manipulative treatment, and the nervous system: a few facts, some theories, many questions. J Am Osteopath Assoc. 1986 Feb;86(2):109-14. No abstract available.
Reference Type
BACKGROUND
Dishman JD, Bulbulian R. Spinal reflex attenuation associated with spinal manipulation. Spine (Phila Pa 1976). 2000 Oct 1;25(19):2519-24;discussion 2525. doi: 10.1097/00007632-200010010-00015.
Reference Type
BACKGROUND
Budgell BS. Reflex effects of subluxation: the autonomic nervous system. J Manipulative Physiol Ther. 2000 Feb;23(2):104-6. doi: 10.1016/s0161-4754(00)90076-9.
Reference Type
BACKGROUND
Bolton PS. Reflex effects of vertebral subluxations: the peripheral nervous system. An update. J Manipulative Physiol Ther. 2000 Feb;23(2):101-3. doi: 10.1016/s0161-4754(00)90075-7.
Reference Type
BACKGROUND
Taylor HH, Murphy B. Altered sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther. 2008 Feb;31(2):115-26. doi: 10.1016/j.jmpt.2007.12.011.
Reference Type
BACKGROUND
DeVocht JW, Pickar JG, Wilder DG. Spinal manipulation alters electromyographic activity of paraspinal muscles: a descriptive study. J Manipulative Physiol Ther. 2005 Sep;28(7):465-71. doi: 10.1016/j.jmpt.2005.07.002.
Reference Type
BACKGROUND
Colloca CJ, Keller TS. Electromyographic reflex responses to mechanical force, manually assisted spinal manipulative therapy. Spine (Phila Pa 1976). 2001 May 15;26(10):1117-24. doi: 10.1097/00007632-200105150-00005.
Reference Type
BACKGROUND
Haavik-Taylor H, Murphy B. Cervical spine manipulation alters sensorimotor integration: a somatosensory evoked potential study. Clin Neurophysiol. 2007 Feb;118(2):391-402. doi: 10.1016/j.clinph.2006.09.014. Epub 2006 Nov 29.
Reference Type
BACKGROUND
Lehman G. Kinesiological research: the use of surface electromyography for assessing the effects of spinal manipulation. J Electromyogr Kinesiol. 2012 Oct;22(5):692-6. doi: 10.1016/j.jelekin.2012.02.010. Epub 2012 Mar 15.
Reference Type
BACKGROUND
Colloca CJ, Keller TS, Gunzburg R. Neuromechanical characterization of in vivo lumbar spinal manipulation. Part II. Neurophysiological response. J Manipulative Physiol Ther. 2003 Nov-Dec;26(9):579-91. doi: 10.1016/j.jmpt.2003.08.004.
Reference Type
BACKGROUND
Colloca CJ, Keller TS, Gunzburg R, Vandeputte K, Fuhr AW. Neurophysiologic response to intraoperative lumbosacral spinal manipulation. J Manipulative Physiol Ther. 2000 Sep;23(7):447-57. doi: 10.1067/mmt.2000.108822.
Reference Type
BACKGROUND
Krishnan C, Williams GN. Error associated with antagonist muscle activity in isometric knee strength testing. Eur J Appl Physiol. 2010 Jun;109(3):527-36. doi: 10.1007/s00421-010-1391-0. Epub 2010 Feb 20.
Reference Type
BACKGROUND
Krishnan C, Williams GN. Variability in antagonist muscle activity and peak torque during isometric knee strength testing. Iowa Orthop J. 2009;29:149-58.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
12-0280-F1V
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Effect of Lower Extremity Joint Manipulation on a Lower Extremity Somatosensory Illusion
NCT05226715
COMPLETED
NA
Clinical Correlates of Pressure Pain Thresholds in Back and Leg Pain
NCT06653920
COMPLETED
Thoracic Spine Manipulation for Individuals With Low Back Pain
NCT02853357
COMPLETED
NA
Effect of Orthopedic Blocking on Cervical Spine Flexion and Extension Strength
NCT00758888
UNKNOWN
NA
Effects of Specific Thoracic Spine Mobilizations on Muscle Activity in a Healthy Volunteer Population
NCT06374862
RECRUITING
NA
Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability
NCT06294132
RECRUITING
NA
Comparison of the Effectiveness of Chiropractic Manipulation Applied to the Lumbar Sacroiliac Region in Patients With Lumbar Disc Herniation
NCT07037641
COMPLETED
NA
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
NCT00939107
COMPLETED
NA
Feasibility Study of Short-Term Effects of Chiropractic Manipulation on Older Adults With Impaired Balance
NCT00497510
COMPLETED
NA
Using MRI Scans to Evaluate Spinal Manipulation
NCT00070902
COMPLETED
PHASE1
Thrust Manipulation Versus Non-Thrust Manipulation
NCT01438203
COMPLETED
PHASE2
Comparison of Balance Changes After Chiropractic Adjustments in Health Adults.
NCT03877367
COMPLETED
NA
The Effect of Chiropractic Manipulation on Spine-related Pain and Balance in Older Adults
NCT00497718
COMPLETED
NA
Balance Chiropractic Therapy for Cervical Spondylotic Radiculopathy
NCT02705131
UNKNOWN
NA
Effects of Cervical Manipulation on Cervical Rotation Motion and Shoulder Rotational Motion and Strength in Overhead Athletes
NCT06903793
COMPLETED
NA
Effects of Manual Therapy Combined With Therapeutic Exercise on Brain Biomarkers in Neck Pain
NCT05568394
COMPLETED
NA
Corticospinal Excitability of Deep Back and Abdominal Muscles
NCT03747185
COMPLETED
NA
The Effect of Manipulations of the Lumbar Spine on Six Different Outcome Measures
NCT00739570
COMPLETED
NA
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
NCT02550132
COMPLETED
NA
Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees
NCT03389334
COMPLETED
NA
Effects of Manual Therapy on Shoulder Function
NCT04513535
COMPLETED
NA
Muscle Activity and Kinematic Changes With Dry Needling
NCT04295200
COMPLETED
NA
The Effect of a Single Spinal Manipulation on Cardiovascular Autonomic Activity
NCT03273868
COMPLETED
NA
Does Manual Therapy Provide Immediate Improvement in Lumbar Range of Motion?
NCT05926674
COMPLETED
NA
Assessing Patient Response to Therapeutic Exercise Based on Clinical Prediction Rule (CPR) for Spinal Manipulation
NCT00916734
COMPLETED
PHASE3