Identification of the Blood Microbiota in Patient Suffering From Myocardial Infraction

NCT ID: NCT02405468

Last Updated: 2016-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

202 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-07-31

Study Completion Date

2015-12-31

Brief Summary

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The investigators want to compare blood microbiota profile between patients with documented coronary lesions and patients free of coronary disease.

Detailed Description

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Conditions

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Coronary Disease Myocardial Infarction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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case

patients with a myocardial infarction within one month to one year before the inclusion

No interventions assigned to this group

control

patients without history of myocardial infarction, free of coronary disease in the view of one of the following test performed within one year before the inclusion : Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with \>= 2 major cardiovascular risk factors :

* Treated hypertension
* Treated dyslipidemia
* Current smoking
* Diabetes mellitus

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Cases : patients who have had a myocardial infarction within one month to one year before the inclusion
* Controls : patients without history of myocardial infarction, free of coronary disease in the view of one of the following tests performed within one year before the inclusion :

Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with \>= 2 major cardiovascular risk factors:

1. Treated hypertension,
2. Treated dyslipidemia
3. Current smoking
4. Diabetes mellitus

Exclusion Criteria

* Infectious disease within one week before the inclusion
* Immunocompromised patients
* Antibiotic treatment within one month before the inclusion
* Chronic viral infection
* Chronic inflammatory intestinal bowel disease
* Renal failure (estimated glomerular filtration rate\< 50 ml/min//1.73 m2)
* Pregnancy
Minimum Eligible Age

35 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Meyer Elbaz, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

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UHToulouse

Toulouse, , France

Site Status

Countries

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France

References

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Amar J, Lelouvier B, Servant F, Lluch J, Burcelin R, Bongard V, Elbaz M. Blood Microbiota Modification After Myocardial Infarction Depends Upon Low-Density Lipoprotein Cholesterol Levels. J Am Heart Assoc. 2019 Oct;8(19):e011797. doi: 10.1161/JAHA.118.011797. Epub 2019 Sep 28.

Reference Type DERIVED
PMID: 31566105 (View on PubMed)

Other Identifiers

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2013-A00337-38

Identifier Type: REGISTRY

Identifier Source: secondary_id

12 387 02

Identifier Type: -

Identifier Source: org_study_id

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