Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients

NCT ID: NCT04358952

Last Updated: 2021-06-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

122 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-04

Study Completion Date

2021-04-02

Brief Summary

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The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown. Epidemiological studies report biological myocardial involvement in 10 to 25% of cases. The objective of this study is to cardiac phenotype using comprehensive cardiac imaging tools of patients infected with Covid 19 in order to explore the functional impact of the infection on the myocardium.

Detailed Description

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A large population of Covid 19 infected patients of different ages and severity levels will be explored by transthoracic echocardiography with measurement of myocardial functional parameters such as ejection fraction, longitudinal strain and relaxation parameters and will be compared to an uninfected population paired for age and sex.

Patients with biological myocardial involvement will be followed to determine the evolution of their myocardial functional parameters during the course of the infection.

Conditions

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Cardiomyopathies

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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COVID + patients

Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Global Longitudinal Strain

Intervention Type DIAGNOSTIC_TEST

Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction

Interventions

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Global Longitudinal Strain

Electrocardiogram with measure of the Global Longitudinal Strain to evaluate myocardiac dysfunction

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Major patients hospitalized for respiratory criteria for SARS-Cov-2 infection confirmed by RT-PCR

Exclusion Criteria

* Underage patients. Patients refusing to participate in research. Patients with a history of heart disease.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Toulouse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vincent MINVILLE, PU-PH

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Toulouse

Locations

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UHToulouse

Toulouse, , France

Site Status

Countries

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France

References

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Lairez O, Blanchard V, Balardy L, Vardon-Bounes F, Cazalbou S, Ruiz S, Collot S, Houard V, Rolland Y, Conil JM, Minville V. COCARDE Study-Cardiac Imaging Phenotype in Patients With COVID-19: Protocol for a Prospective Observational Study. JMIR Res Protoc. 2022 Jan 6;11(1):e24931. doi: 10.2196/24931.

Reference Type DERIVED
PMID: 34751159 (View on PubMed)

Other Identifiers

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2020-A00852-37

Identifier Type: OTHER

Identifier Source: secondary_id

RC31/20/0117

Identifier Type: -

Identifier Source: org_study_id

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