Antagonist Protocol in IVF

NCT ID: NCT02335736

Last Updated: 2016-02-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2016-04-30

Brief Summary

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The antagonist protocol in a novel method of stimulation in the in vitro fertilization (IVF) patients. It has been tried in poor responders, polycystic ovary (PCO) patients and normal females undergoing IVF. Can it be used with the same efficacy in all patients?

Detailed Description

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Conditions

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Infertility

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Normal

Human menopausal gonadotrophin IM daily was administrated from day 2 of the cycle. The Gonadotropins releasing hormone antagonist GnRH ant (Cetrotide, Serono, Geneva, Switzerland) was given when the leading follicle was from 12 to 14 mm, at a daily dose of 0.25 mg SC.

Group Type ACTIVE_COMPARATOR

Gonadotropins releasing hormone antagonist

Intervention Type DRUG

Poor responders

Human menopausal gonadotrophin IM daily was administrated from day 2 of the cycle. The Gonadotropins releasing hormone antagonist GnRH ant (Cetrotide, Serono, Geneva, Switzerland) was given when the leading follicle was from 12 to 14 mm, at a daily dose of 0.25 mg SC

Group Type ACTIVE_COMPARATOR

Gonadotropins releasing hormone antagonist

Intervention Type DRUG

Polycystic ovarian disease

Human menopausal gonadotrophin IM daily was administrated from day 2 of the cycle. The Gonadotropins releasing hormone antagonist GnRH ant(Cetrotide, Serono, Geneva, Switzerland) was given when the leading follicle was from 12 to 14 mm, at a daily dose of 0.25 mg SC

Group Type ACTIVE_COMPARATOR

Gonadotropins releasing hormone antagonist

Intervention Type DRUG

Interventions

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Gonadotropins releasing hormone antagonist

Intervention Type DRUG

Other Intervention Names

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Cetrotide, Serono, Geneva, Switzerland

Eligibility Criteria

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Inclusion Criteria

* age: 20- 44 years
* Poor responder females according to Bologna criteria
* Polycystic ovarian disease females according to Rotterdam criteria
* Females with infertility causes other than poor responders, or PCO; male factor or tubal block

Exclusion Criteria

* refusal to get enrolled in the study
* cases of infertility due to severe male factor
Minimum Eligible Age

20 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role collaborator

Woman's Health University Hospital, Egypt

OTHER

Sponsor Role lead

Responsible Party

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Dina Mohamed Refaat Dakhly

lecturer of obstetrics and gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dina M Dakhly, MD

Role: PRINCIPAL_INVESTIGATOR

Cairo University

Locations

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Kasr el aini hospital

Cairo, Cairo Governorate, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Dina M Dakhly, MD

Role: CONTACT

01003498919 ext. 002

mohamed abdalla, MD

Role: CONTACT

01001721206 ext. 002

Facility Contacts

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Dina M Dakhly, MD

Role: primary

01003498919 ext. 002

Other Identifiers

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AA2015

Identifier Type: -

Identifier Source: org_study_id

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