Neurophysiological Study of tDCS Effects in Healthy Volunteers

NCT ID: NCT02125422

Last Updated: 2015-05-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-11-30
• Study Completion Date: 2014-04-30

Brief Summary

Transcranial direct current stimulation is a tool to modulate cortical excitability.

Detailed Description

Anodal transcranial direct currenti stimulation over visual cortex is able to decrease the thermo-nociceptive sensibility and thermonociceptive potentials, whilst cathodal transcranial direct current stimulation has the opposite effect, it decreases VEP amplitude and habituation. This neuromodulation technique is probably a tool in the prevention in episodic and chronic migraine.

The aim of the study is to study short and long term effect of tDCS over pain treshold, contact heat evoked potentials, blink reflex and visual evoked potentials in healthy volunteers.

Conditions

Healthy Volunteers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Cefaly tDCS

Cathodal Cefaly tDCS is delivered over the visual cortex at 2 mA of intensity, for 20 minutes, for 5 consecutive days in 9 HV. The anode is placed over the left DLPFC.

2 mA anodal tDCS is delivered over the visual cortex, for 20 minutes, for 5 consecutive days in 9 HV

Group Type: EXPERIMENTAL

Cefaly tDCS

Intervention Type: DEVICE

Cefaly tDCS (transcranial direct current stimulation) is able to modify cortical excitability, in particular anodal tDCS increases it. The side effects of tDCS are minor, especially sensations of itching and scalp paresthesias.

Interventions

Cefaly tDCS

Cefaly tDCS (transcranial direct current stimulation) is able to modify cortical excitability, in particular anodal tDCS increases it. The side effects of tDCS are minor, especially sensations of itching and scalp paresthesias.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• healthy volunteers

Exclusion Criteria

• age below 18 or above 65 years
• personal history of recurrent headache or other neurological diseases especially seizures,
• familial history of recurrent headache
• child migraine equivalents (motion sickness, cyclic vomiting or recurrent abdominal pain, somnambulism etc.. . .)
• chronic pain syndromes
• analgesics intake at the time of recording
• contra-indications to tDCS neurostimulation (metal prosthetics in the head or internal stimulation like a pacemaker).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Liege

OTHER

Sponsor Role: lead

Responsible Party

Jean Schoenen

Honorary Full Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Delphine Magis, MD

Role: PRINCIPAL_INVESTIGATOR

University of Liege

Jean Schoenen, MD

Role: PRINCIPAL_INVESTIGATOR

University of Liege

Locations

Roberta Baschi

Liége, Liége, Belgium

Countries

Belgium

Other Identifiers

CB-1200

Identifier Type: -

Identifier Source: org_study_id