Impact of tDCS on Cerebral Autoregulation

NCT ID: NCT01865604

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2014-03-31

Brief Summary

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The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.

Detailed Description

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Conditions

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Cerebral Microangiopathy CADASIL Migraine With Aura ICA Stenosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Anodal tDCS

anaodal transcranial direct current stimulation

Group Type EXPERIMENTAL

Anodal tDCS

Intervention Type DEVICE

Cathodal tDCS

cathodal transcranial direct current stimulation

Group Type ACTIVE_COMPARATOR

Cathodal tDCS

Intervention Type DEVICE

Sham tDCS

no stimulation

Group Type SHAM_COMPARATOR

sham tDCS

Intervention Type DEVICE

Interventions

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Anodal tDCS

Intervention Type DEVICE

Cathodal tDCS

Intervention Type DEVICE

sham tDCS

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. severe cerebral Microangiopathy
2. NOTCH3 carrier
3. Migraine with aura (IHS Classification ICHD-II)
4. Stenosis \>80%, ECST-Criteria

Exclusion Criteria

* seizure disorder
* history of severe alcohol or drug abuse, psychiatric illness like severe depression, poor motivational capacity
* dementia

(1+2) history of stroke in past 3 months (3) migraine prophylaxis (4) contralateral stenosis \>50%,
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Agnes Flöel

Prof. Dr. med. Agnes Floeel

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Agnes Flöel, Prof. MD

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Department of Neurology, Charité Universitätsmedizin Berlin

Berlin, State of Berlin, Germany

Site Status

Countries

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Germany

Other Identifiers

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tDCS_cVMR

Identifier Type: -

Identifier Source: org_study_id

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