Effect of Transcutaneous Electrical Nerve Stimulation on Cognition in Multiple Sclerosis Patients
NCT ID: NCT02876536
Last Updated: 2016-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2016-06-30
2016-09-30
Brief Summary
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Detailed Description
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In some studies on rats, stimulation of somatosensory neurons has improved the hippocampus activity by increasing the amount of acetylcholine. Hippocampus has a major role in cognition and behavior.
TENS is a non-invasive method in which the electrical pulses are sent to the body trough skin by electrodes. This device can stimulate the somatosensory neurons by electrical impulses. In several studies, the effect of TENS has been proved on short term memory and verbal fluency in patients with mild stages of Alzheimer disease. Also it has been effective on some aspects of cognition on old people suffering from forgetfulness.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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TNES with sending electrical impulses
The MS patients will receive electrical impulses by TENS device for 30 minutes a day, for 5 days a week and in 6 weeks
TENS
The effect of TENS device will be compared in case and control groups.
TENS without sending electrical impulses
The MS patients will use the TENS device for 30 minutes a day, for 5 days a week and in 6 weeks without receiving any electrical impulses
TENS
The effect of TENS device will be compared in case and control groups.
Interventions
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TENS
The effect of TENS device will be compared in case and control groups.
Eligibility Criteria
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Inclusion Criteria
* score 25 or less in mini mental state examination (MMSE)
Exclusion Criteria
* the history of psychiatric problems;
* addiction to alcohol; head trauma; cerebrovascular disease; hydrocephalus; neoplasm; epilepsy; renal or respiratory diseases; impaired consciousness
ALL
No
Sponsors
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Isfahan University of Medical Sciences
OTHER
Responsible Party
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Leila Dehghani
assistant prof
Principal Investigators
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Vahid Shaygannezhad, professor
Role: STUDY_DIRECTOR
Isfahan MS Society, Isfahan University of Medical Sciences, Isfahan, Iran
Locations
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Alzahra Hospital
Isfahan, , Iran
Countries
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Central Contacts
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Other Identifiers
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Isfahan MS society
Identifier Type: -
Identifier Source: org_study_id
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