The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
NCT ID: NCT02109133
Last Updated: 2015-06-24
Study Results
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View full resultsBasic Information
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COMPLETED
NA
67 participants
INTERVENTIONAL
2014-05-31
2014-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Deep neuromuscular blockade
Deep neuromuscular blockade
deep neuromuscular blockade
deep neuromuscular blockade using rocuronium and reverse with sugammadex
Rocuronium
Sugammadex
moderate neuromuscular blockade
moderate neuromuscular blockade
moderate neuromuscular blockade
moderate neuromuscular blockade using atracurium and reverse with neostigmine
Atracurium
Neostigmine
Interventions
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deep neuromuscular blockade
deep neuromuscular blockade using rocuronium and reverse with sugammadex
moderate neuromuscular blockade
moderate neuromuscular blockade using atracurium and reverse with neostigmine
Rocuronium
Sugammadex
Atracurium
Neostigmine
Eligibility Criteria
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Inclusion Criteria
2. obtaining written informed consent from the parents
3. aged over 50 years who were undergoing robot- assisted laparoscopic prostatectomy
Exclusion Criteria
2. unstable angina or congestive heart failure
3. concomitant eye disease (glaucoma, diabetic retinopathy, cataract, retinal detachment)
4. high intraocular pressure over 30mmHg after screening test.
5. uncontrolled hypertension (diastolic bp\>110mmHg)
6. coagulopathy
7. asthma
8. hepatic failure
9. renal failure(creatinine clearance \< 30 ml/min)
10. drug hyperactivity
11. neurological or psychiatric illnesses
12. mental retardation
13. patients who can't read the consent form due to illiterate or foreigner
14. previous malignant hyperthermia Hx
15. drug medication which interact with muscle relaxant (anti-convulsant, certain antibiotics, magnesium etc)
16. BMI \> 30kg/m2
50 Years
80 Years
MALE
Yes
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, Seoul, South Korea
Countries
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References
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Yoo YC, Kim NY, Shin S, Choi YD, Hong JH, Kim CY, Park H, Bai SJ. The Intraocular Pressure under Deep versus Moderate Neuromuscular Blockade during Low-Pressure Robot Assisted Laparoscopic Radical Prostatectomy in a Randomized Trial. PLoS One. 2015 Aug 28;10(8):e0135412. doi: 10.1371/journal.pone.0135412. eCollection 2015.
Other Identifiers
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4-2014-0058
Identifier Type: -
Identifier Source: org_study_id
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