Effect of Mannitol on Optic Nerve Sheath Diameter in Patients Undergoing Robotic Prostatectomy

NCT ID: NCT03214055

Last Updated: 2017-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-07-12

Study Completion Date

2017-08-20

Brief Summary

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We aim to evaluate the change in optic nerve sheath diameters as a surrogate of intracranial pressure before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy with pneumoperitoneum and Trendelenburg position.

Detailed Description

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Mannitol has been frequently used for renal protection during surgery. Optic nerve sheath diameter is used to evaluate intracranial pressure noninvasively. Robot-assisted laparoscopic radical prostatectomy can induce an increase in optic nerve sheath diameter due to Trendelenburg position and carbon dioxide insufflation. We therefore aim to evaluate the change in optic nerve sheath diameters before and after mannitol administration in patients who undergo robot assisted laparoscopic radical prostatectomy.

Conditions

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Prostate Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Mannitol

The mannitol has been administered routinely to prevent renal dysfunction in patients undergoing robot-assisted laparoscopic radical prostatectomy. Participants will receive the mannitol as part of routine medical care, and we will evaluate the change in optic nerve sheath diameters before and after mannitol administration.

Intervention Type DRUG

Other Intervention Names

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Osmotic diuretic

Eligibility Criteria

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Inclusion Criteria

* prostate cancer patients undergoing robot assisted laparoscopic radical prostatectomy.
* 20 year old or above, 79 year old or below.
* agreed to participate this study.

Exclusion Criteria

* history of cerebrovascular accident.
* history of congestive heart failure.
* history of pulmonary edema.
* history of anaphylaxis to mannitol.
* conversion to open prostatectomy.
* combined with other operation.
* inability to measure optic nerve sheath diameter.
Minimum Eligible Age

20 Years

Maximum Eligible Age

79 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Young-Kug Kim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Young-Kug Kim, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

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Asan Medical center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2017-0789

Identifier Type: -

Identifier Source: org_study_id

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