The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery

NCT ID: NCT01325844

Last Updated: 2012-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2011-10-31

Brief Summary

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This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery. The investigators hypothesized that epidural anesthesia will effectively block the activation of the sympathetic nervous system during surgery, thus activating nitric oxide and reducing splanchnic ischemia and decrease in postoperative renal function.

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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G group

G group = General anesthesia group

Group Type NO_INTERVENTION

No interventions assigned to this group

G+E group

G+E group = General anesthesia + epidural anesthesia group

Group Type EXPERIMENTAL

Epidural anesthesia

Intervention Type PROCEDURE

0.5% ropivacaine infusion via epidural catheter at 5ml/hr during general anesthesia

Interventions

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Epidural anesthesia

0.5% ropivacaine infusion via epidural catheter at 5ml/hr during general anesthesia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ASA class 1 or 2 adult patients scheduled for endoscopic prostatectomy

Exclusion Criteria

* Patient refusal
* Patients on diuretics
* Patients with renal failure (eGFR \< 60 ml/min/1.73 m2)
Minimum Eligible Age

20 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Severance Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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4-2010-0537

Identifier Type: -

Identifier Source: org_study_id

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