Effects of IV Chloride Content on Outcomes

NCT ID: NCT02083198

Last Updated: 2017-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1558 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-30

Study Completion Date

2014-04-01

Brief Summary

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This observational study evaluates the impact of high and low chloride containing IV fluids on administrative and clinical outcomes. The study uses a large electronic health dataset and examines patients receiving fluid replacement and resuscitation. The hypothesis is that high chloride solutions are associated with adverse outcomes as measured by administrative data and by clinical parameters.

Detailed Description

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Conditions

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SIRS Balanced Fluids Plasmalyte

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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High Chloride

Patients receiving .9% sodium choride for resuscitation

No interventions assigned to this group

Low chloride

Patients receiving Plasmalyte for resuscitation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adults meeting SIRS criteria receiving at least 500 mL of fluid replacement on day of SIRS.

Exclusion Criteria

* Receipt of starches or other colloids
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Baxter Healthcare Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Baxter Healthcare

Deerfield, Illinois, United States

Site Status

Countries

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United States

References

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Shaw AD, Schermer CR, Lobo DN, Munson SH, Khangulov V, Hayashida DK, Kellum JA. Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care. 2015 Sep 12;19(1):334. doi: 10.1186/s13054-015-1045-z.

Reference Type DERIVED
PMID: 26370823 (View on PubMed)

Other Identifiers

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Bax-BSP-HiLoCl

Identifier Type: -

Identifier Source: org_study_id

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