CSF Cholinergic Biomarkers and Postoperative Cognitive Change

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

102 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-07-31

Study Completion Date

2016-07-31

Brief Summary

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Previous study demonstrated that the condition of central cholinergic nerve is important for the postoperative cognitive dysfunction. In present study investigators hypothesized that the acetylcholine concentration in the cerebral spinal fluid is associated to the postoperative cognitive changes in aged patients undergoing osteopathic surgery.

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Detailed Description

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Conditions

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Necrosis of Femoral Head Knee Osteoarthritis Fracture of Lower Limb

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Elder than 60 years old
* Spoke proficient Mandarin Chinese
* Agree to undergoing spinal plus general anesthesia
* Selected total knee replacement surgery

Exclusion Criteria

* Patients with neurological and/or psychiatric diseases, including AD, stroke and psychosis
* Have contraindication for spinal anesthesia such as clotting disorder local infection in the puncture site
* Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
* Several audition or vision disorder
* Unwillingness to comply with the protocol or procedures.

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No