Study Results
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View full resultsBasic Information
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COMPLETED
NA
27 participants
INTERVENTIONAL
2023-01-09
2025-07-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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Blood pressure managed by cerebral autoregulation
In this arm cerebral autoregulation monitoring will be used to determine the lower and upper limits of cerebral autoregulation. Monitoring will continue throughout the surgery. Blood pressure management will be maintained to be within the limits of cerebral autoregulation.
Blood pressure management according to cerebral autoregulation
Intraoperative blood pressure will be targeted based on limits of cerebral autoregulation.
Standard of care blood pressure management
In this arm cerebral autoregulation monitoring will be used for observation. The anesthesia provider will use usual care guidelines for blood pressure management.
Blood pressure management according to usual care
Intraoperative blood pressure will be targeted based on usual care.
Interventions
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Blood pressure management according to cerebral autoregulation
Intraoperative blood pressure will be targeted based on limits of cerebral autoregulation.
Blood pressure management according to usual care
Intraoperative blood pressure will be targeted based on usual care.
Eligibility Criteria
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Inclusion Criteria
* age ≥60
* ambulatory at baseline
* expected duration of surgery \> 90 minutes
Exclusion Criteria
* Allergy to adhesive tape
* Short Blessed Test score \>20
* Clinical diagnosis of dementia
* Opinion of either the anesthesiologist or surgeon that the patient is not appropriate.
60 Years
100 Years
ALL
No
Sponsors
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National Institute on Aging (NIA)
NIH
Johns Hopkins University
OTHER
Responsible Party
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Principal Investigators
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Charles Brown, MD
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Locations
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The Johns Hopkins University
Baltimore, Maryland, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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IRB00137091
Identifier Type: -
Identifier Source: org_study_id
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