Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers

NCT ID: NCT01981746

Last Updated: 2014-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-30

Study Completion Date

2013-12-31

Brief Summary

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To investigate whether reducing the volume (30 versus 10 ml) ropivacaine injected can reduce the number of subjects with impaired muscle strength following adductor canal block. We hypothesized that adductor canal block with 10 ml 0.1% ropivacaine preserves quadriceps strength compared with an adductor canal block with 30 ml.

Detailed Description

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Conditions

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Muscle Strength Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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30 ml

30 ml ropivacaine 0.1%, single bolus

Group Type EXPERIMENTAL

Adductor canal block with ropivacaine 0.1%

Intervention Type PROCEDURE

US-guided adductor canal block

10 ml

10 ml 0.1% ropivacaine, single bolus

Group Type EXPERIMENTAL

Adductor canal block with ropivacaine 0.1%

Intervention Type PROCEDURE

US-guided adductor canal block

Interventions

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Adductor canal block with ropivacaine 0.1%

US-guided adductor canal block

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 18-30 years
* Men
* ASA 1
* Body Mass Index 18-25

Exclusion Criteria

* Allergy to study medication
* Earlier trauma or surgery to the lower limb
* Diabetes Mellitus
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Pia Jaeger

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Pia Jaeger, MD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Locations

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Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Jaeger P, Grevstad U, Koscielniak-Nielsen ZJ, Sauter AR, Sorensen JK, Dahl JB. Does dexamethasone have a perineural mechanism of action? A paired, blinded, randomized, controlled study in healthy volunteers. Br J Anaesth. 2016 Nov;117(5):635-641. doi: 10.1093/bja/aew318.

Reference Type DERIVED
PMID: 27799178 (View on PubMed)

Jaeger P, Koscielniak-Nielsen ZJ, Hilsted KL, Fabritius ML, Dahl JB. Adductor Canal Block With 10 mL Versus 30 mL Local Anesthetics and Quadriceps Strength: A Paired, Blinded, Randomized Study in Healthy Volunteers. Reg Anesth Pain Med. 2015 Sep-Oct;40(5):553-8. doi: 10.1097/AAP.0000000000000298.

Reference Type DERIVED
PMID: 26237001 (View on PubMed)

Other Identifiers

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SM2-PJ-13

Identifier Type: -

Identifier Source: org_study_id

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