The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

NCT ID: NCT01272921

Last Updated: 2017-04-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

142 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Brief Summary

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The duration of motor block for infragluteal parabiceps sciatic nerve block following total knee replacement may vary between 12-36 hrs depending on the amount of local anesthetic given.

Detailed Description

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Conditions

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The Duration of Motor Block May Vary Between 12-36 Hrs

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Bupivacaine

Varying does to determine duration of analgesia following a sciatic nerve block

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

Varying doses to determine the duration of analgesia

Ropivacaine

Varying does to determine duration of analgesia following a sciatic nerve block

Group Type ACTIVE_COMPARATOR

Ropivacaine

Intervention Type DRUG

Varying doses to determine the duration of analgesia

Interventions

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Bupivacaine

Varying doses to determine the duration of analgesia

Intervention Type DRUG

Ropivacaine

Varying doses to determine the duration of analgesia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult patients (\>18 years of age) who are undergoing elective total knee arthroplasty will be included in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Antoun Nader

Professor in Anesthesiology and Orthopaedic Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Antoun Nader, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University Feinberg School of Medicine

Locations

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Northwestern University, Feingberg School of Medicine

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Nader A, Kendall MC, De Oliveira GS Jr, Puri L, Tureanu L, Brodskaia A, Asher Y, Parimi V, McCarthy RJ. A dose-ranging study of 0.5% bupivacaine or ropivacaine on the success and duration of the ultrasound-guided, nerve-stimulator-assisted sciatic nerve block: a double-blind, randomized clinical trial. Reg Anesth Pain Med. 2013 Nov-Dec;38(6):492-502. doi: 10.1097/AAP.0b013e3182a4bddf.

Reference Type DERIVED
PMID: 24108248 (View on PubMed)

Other Identifiers

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STU00035380

Identifier Type: -

Identifier Source: org_study_id

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