The Evaluation of Infant Formulas Fed to Infants With Common Feeding Problems

NCT ID: NCT01934257

Last Updated: 2013-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

296 participants

Study Classification

INTERVENTIONAL

Study Start Date

1994-06-30

Study Completion Date

1996-06-30

Brief Summary

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This clinical trial will determine if the formula given to infants experiencing fussiness, crying, cramping, gas, and/or diarrhea, is accepted and well tolerated and helps to resolve symptoms.

Detailed Description

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Conditions

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Common Infant Feeding Problems

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Marketed milk-based lactose-containing infant formula

Group Type OTHER

Marketed milk-based lactose-containing infant formula

Intervention Type OTHER

Marketed milk-based lactose-free infant formula

Group Type OTHER

Marketed milk-based lactose-free infant formula

Intervention Type OTHER

Marketed soy-based lactose-free infant formula

Group Type OTHER

Marketed soy-based lactose-free infant formula

Intervention Type OTHER

Interventions

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Marketed milk-based lactose-containing infant formula

Intervention Type OTHER

Marketed milk-based lactose-free infant formula

Intervention Type OTHER

Marketed soy-based lactose-free infant formula

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject is between 2 and 12 weeks of age
* Subject has currently been receiving a milk-based lactose-containing formula for at least 5 days as the sole item of diet
* Subject has never switched to any lactose free formula
* The parent/guardian who will fill out the quality of life questionnaire is female and at least 18 years of age
* The parent/guardian has reported an unsolicited history of feeding problems including fussiness/crying/cramping, gas, or diarrhea
* Signed Informed Consent

Exclusion Criteria

* Subject is in daycare for more than 4 hours per day (20 hours per week)
* Subject has serious perinatal complications, underlying disease or congenital malformations that impair normal formula feeding
* The parent/guardian who will fill out the quality of life questionnaire has chronic illness, e.g. diabetes, inflammatory bowel disease or other illness requiring daily medication or treatment
* Subject has acute infectious diarrhea or any other intercurrent illness
Minimum Eligible Age

2 Weeks

Maximum Eligible Age

12 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mead Johnson Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Colin Rudolph, M.D., Ph.D

Role: STUDY_DIRECTOR

Mead Johnson & Company

Locations

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Dr. Mark Pearlman

Aurora, California, United States

Site Status

Gould Medical Foundation

Modesto, California, United States

Site Status

Memorial Medial Center Research

Savannah, Georgia, United States

Site Status

Welborn Clinic Peds

Evansville, Indiana, United States

Site Status

Riveria Pediatrics

Indianapolis, Indiana, United States

Site Status

Kentucky Pediatrics

Bardstown, Kentucky, United States

Site Status

Kids Med South

Baton Rouge, Louisiana, United States

Site Status

The Pediatric Group

Princeton, New Jersey, United States

Site Status

Chapel Hill Pediatrics

Durham, North Carolina, United States

Site Status

Henderson Pediatrics

Fletcher, North Carolina, United States

Site Status

Matthews Children Group

Matthews, North Carolina, United States

Site Status

Capital Pediatrics

Raleigh, North Carolina, United States

Site Status

Pediatric Medical Associates

Havertown, Pennsylvania, United States

Site Status

Pennridge Pediatrics

Sellersville, Pennsylvania, United States

Site Status

Pittsburgh Pediatric Research

Upper Saint Clair, Pennsylvania, United States

Site Status

Lewis Gale Clinic

Salem, Virginia, United States

Site Status

Vancouver Clinic

Vancouver, Washington, United States

Site Status

Rhinelander Medical Center

Rhinelander, Wisconsin, United States

Site Status

Dr. David Conner

Winnipeg, Manitoba, Canada

Site Status

Countries

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United States Canada

References

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Sherman AL, Anderson J, Rudolph CD, Walker LS. Lactose-Free Milk or Soy-Based Formulas Do Not Improve Caregivers' Distress or Perceptions of Difficult Infant Behavior. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):119-24. doi: 10.1097/MPG.0000000000000743.

Reference Type DERIVED
PMID: 25643020 (View on PubMed)

Other Identifiers

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3332-5

Identifier Type: -

Identifier Source: org_study_id