Growth and Tolerance of Infants Fed Milk-Based Infant Formula

NCT ID: NCT03967132

Last Updated: 2020-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

189 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-06-08

Study Completion Date

2020-05-29

Brief Summary

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The purpose of this study is to evaluate growth and tolerance of healthy term infants fed an experimental milk-based infant formula with oligosaccharides compared to a control milk-based infant formula.

Detailed Description

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Conditions

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Gastro-Intestinal Tolerance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Control Infant Formula

Milk-based infant formula

Group Type ACTIVE_COMPARATOR

Control Infant Formula

Intervention Type OTHER

Ready to feed infant formula, feed ad libitum

Experimental Infant Formula

Milk-based Infant Formula with oligosaccharides

Group Type EXPERIMENTAL

Experimental Infant Formula

Intervention Type OTHER

Ready to feed infant formula, feed ad libitum

Reference Group

Human-milk fed

Group Type OTHER

Reference Group

Intervention Type OTHER

Human milk, breast feeding ad libitum

Interventions

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Control Infant Formula

Ready to feed infant formula, feed ad libitum

Intervention Type OTHER

Experimental Infant Formula

Ready to feed infant formula, feed ad libitum

Intervention Type OTHER

Reference Group

Human milk, breast feeding ad libitum

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Good health as determined from participant's medical history
* Singleton from a full-term birth with a gestational age of 37-42 weeks
* Birth weight was \> 2490 g (\~5 lbs. 8 oz.)
* If parent(s) of the participant elect to formula-feed the participant, parent(s) confirm the participant has not been given human milk since being discharged from the hospital following birth, and confirm their intention to feed their infant the study product as the sole source of feeding from Study Visit 1-Visit 7, unless instructed otherwise by their healthcare professional.
* If parent(s) of the participant elect to feed the infant human milk, they confirm the infant has not received any formula prior to enrollment, and confirm their intention to exclusively feed human milk from birth, and as the sole source of feeding from Study Visit 1-Visit 7.
* Parent(s) confirm their intention not to administer vitamin or mineral supplements (with the exception of Vitamin D supplements), solid foods or juices to their infant from enrollment through the duration of the study, unless instructed otherwise by their healthcare professional.
* Participant's parent(s) has voluntarily signed and dated an ICF, approved by an IRB/IEC and provided HIPAA (or other applicable privacy regulation) authorization prior to any participation in the study.

Exclusion Criteria

* An adverse maternal, fetal or participant medical history that is thought by the investigator to have potential for effects on tolerance, growth, and/or development.
* Participant is taking and plans to continue taking medications (including over the counter (OTC), such as Mylicon® for gas), prebiotics, probiotics, home remedies (such as juice for constipation), herbal preparations or rehydration fluids that might affect GI tolerance.
* Participant participates in another study that has not been approved as a concomitant study by AN.
Maximum Eligible Age

14 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Abbott Nutrition

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Timberly Williams, PhD

Role: STUDY_CHAIR

Abbott Nutrition

Locations

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Watching Over Mothers & Babies

Tucson, Arizona, United States

Site Status

Pediatric Medical Associates

Sacramento, California, United States

Site Status

Norwich Pediatric Group, P.C.

Norwich, Connecticut, United States

Site Status

Phoenix Medical Research LLC

Miami, Florida, United States

Site Status

University Clinical Research-Deland, LLC a/b/a Accel Clinical Research

Orlando, Florida, United States

Site Status

Clinical Research Prime

Idaho Falls, Idaho, United States

Site Status

Deaconess Clinic, Inc.

Evansville, Indiana, United States

Site Status

Michael W. Simon, M.D., PSC

Nicholasville, Kentucky, United States

Site Status

Springs Medical Research

Owensboro, Kentucky, United States

Site Status

Institute of Clinical Research, LLC

Mentor, Ohio, United States

Site Status

The Cleveland Pediatric Research Center, LLC

Middleburg Heights, Ohio, United States

Site Status

Holston Medical Group

Kingsport, Tennessee, United States

Site Status

Midsouth Center for Clinical Research

Memphis, Tennessee, United States

Site Status

ARC Clinical Research at Wilson Parke

Austin, Texas, United States

Site Status

Ventavia Research Group, LLC

Fort Worth, Texas, United States

Site Status

Ventavia Research Group

Houston, Texas, United States

Site Status

Ventavia Research Group, LLC 3078

Keller, Texas, United States

Site Status

Kagan Pediatrics - HD Research Corporation

Pearland, Texas, United States

Site Status

Plano Pediatrics - ACRC Trials

Plano, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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AL29A

Identifier Type: -

Identifier Source: org_study_id

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