Glycemic Index of Mango and Pear in Different Solid Products and Drinks
NCT ID: NCT01929551
Last Updated: 2014-09-04
Study Results
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Basic Information
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COMPLETED
NA
38 participants
INTERVENTIONAL
2013-08-31
2013-11-30
Brief Summary
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Detailed Description
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Each participant will receive a different product (of the seven products available) each day of the test (8 days in total), making sure everyone receives each one of the products. All products will be distributed in a randomized fashion for each of the participants. The 50-gram glucose load (gold standard) will be the reference or control, and will be taken twice by each subject in the test.
Each one of the products given will contain 50 grams of carbohydrate. The time given to consume the products will be 10 minutes total.
There will be a "wash out" period of three days in between each product.
The participants will eat the product and capillary glucose will be taken with a glucometer (Accu-Chek Performa System © 2009 Roche Diagnostics. Roche Products, México) at times: 0, 15, 30, 45, 60, 75, 90, 150 and 120 minutes. The glucometer will be calibrated with a standard glucose solution every day previous to the test. The results will be used to calculate the glycemic index. At the end of the 120 minutes, the participants will receive a questionnaire of digestive symptoms presented during the test.
The glycemic index will be calculated by the area under the curve for each product divided by the area under the curve for the 50-gram glucose load, multiplied by 100. The area under the curve used to calculate the glycemic index is the area that surpasses the basal line, excluding the area under the basal line according to the Food and Agriculture Organization (FAO) in 1998 (Brouns et al 2005).
All information collected will be emptied into a pre-designed database.
The differences between the different products ingested will be analyzed with the statistical test of analysis of variance (ANOVA) with a pre-test of homogeneity of variance Brown-Foryhte. In case of failure to find homogeneity in the variances the nonparametric ANOVA, the Kruskal-Wallis test, will be used. The results will be expressed as mean ± standard deviation for each with a significance level of 0.05 for all the statistical tests.
After ANOVA, Tuckey Multiple Comparisons test will be used to evaluate the pairwise relationship for each product.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
NONE
Study Groups
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Mango puree and pear juice beverage
Participants will drink 450 milliliters of the juice at time 0.
Mango puree and pear juice beverage
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Commercial mango juice
Participants will drink 450 milliliters of the juice at time 0.
Commercial mango juice
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Fresh natural mango
Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.
Fresh natural mango
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Frozen natural mango
Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.
Frozen natural mango
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Processed natural mango pulp
Participants will eat 400 to 500 grams of frozen mango pulp, along with 250 milliliters of water at time 0.
Processed natural mango pulp
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Mix of natural mango and pear
Participants will eat 400 to 500 grams of a mixture of fresh natural fruit containing mango (73%) and pear (27%), along with 250 milliliters of water at time 0.
Mix of natural mango and pear
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
50 grams glucose load
Participants will drink 250 milliliters of the standard glucose load at time 0.
50 grams glucose load
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Interventions
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Mango puree and pear juice beverage
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Commercial mango juice
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Fresh natural mango
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Frozen natural mango
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Processed natural mango pulp
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Mix of natural mango and pear
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
50 grams glucose load
Capillary glucose will be taken every 15 minutes for two hours (starting at time 0) to calculate the area under the curve which is the glycemic index, for each of the products.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Ages 18 to 50 years
* Body mass index between 18.5 and 27.4 kilograms divided by squared meters
* Waist circumference ≤ 102 centimeters for men and ≤88 centimeters for women
* Fasting capillary glucose ≤100 milligrams per deciliter
The night before the study:
* 10 hours fasting
* Light dinner of their choice and repeat it every time before the study
* No alcohol, coffee or tea drinks the previous night
* No vigorous exercise the day before the test nor the morning of the test
Exclusion Criteria
* Acute or chronic gastrointestinal infections
* Breast feeding or pregnant women
* Intestinal surgeries in the last 6 months
* Allergies to any of the products we will be using
* Subjects with gastrointestinal or metabolic diseases
* Subjects with first grade family history of diabetes mellitus
* Subjects with glucose intolerance, insulin resistance or diabetes mellitus
* Subjects who dislike any of the products we will be using
* Subjects with an acute (previous 24 hours) digestive crisis including: gastritis, diarrhea, and vomit, among others
* Subjects with a history of mal-absorption
Suspension:
* Subjects that do not arrive at the test-day
* Fasting glucose ≥ 100 milligrams per deciliter the day of the test
* Subjects who develop gastrointestinal disease during the study time frame
18 Years
50 Years
ALL
Yes
Sponsors
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Instituto Tecnologico y de Estudios Superiores de Monterey
OTHER
Responsible Party
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Leticia Elizondo-Montemayor
M.D.
Principal Investigators
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Leticia Elizondo-Montemayor, MD
Role: PRINCIPAL_INVESTIGATOR
Clinical Nutrition and Obesity Research Center. TEC Salud, School of Medicine and Health Sciences. Instituto Tecnologico y de Estudios Superiores de Monterrey
Locations
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Clinical Nutrition and Obesity Research Center. School of Medicine and Health Sciences, TEC Salud, Tecnológico de Monterrey
Monterrey, Nuevo León, Mexico
Countries
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References
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Other Identifiers
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IGPMJP2013-CINCO
Identifier Type: -
Identifier Source: org_study_id
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