Assessing the Impact of Calcium Channel Blockers on COGnitive Function in the Very Elderly (AI-COG)

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

337 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-06-30

Study Completion Date

2016-02-29

Brief Summary

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Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline. A particular type of blood pressure lowering drug (a calcium channel blocker(CCB)) may lower risk of dementia in younger adults but there is no clear evidence of it's impact in those \>=80. It is important that we know whether CCB use impacts on cognitive function in this age group. This study will examine the impact of antihypertensives on change in cognitive function with a particular focus on CCBs.

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Detailed Description

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This study is an observational cohort study examining cognitive change in those participants taking antihypertensives and aged 80 and over and examining cognitive change in participants taking different types of antihypertensive medication.

Conditions

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Cognitive Ability, General High Blood Pressure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort of older adults taking antihypertensives

Adults aged 80 and over treated with antihypertensive drugs

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Aged 80 and over Receiving pharmacological treatment for hypertension Mini Mental State Exam score \>24 No other condition likely to limit life to less than one year or to prevent the taking of informed consent.

Exclusion Criteria

Aged under 80 years Not receiving pharmacological treatment for hypertension Mini Mental State Exam score \<25 Diagnosed with a condition likely to limit life to less than one year or to prevent the taking of informed consent.

Presence of a sensory impairment or an existing neuropsychological deficit of sufficient severity to prevent cognitive testing.

Presence of a condition that will prevent cognitive testing, registered blind, profoundly deaf, suffering from an aphasia.

Minimum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No