The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly

NCT ID: NCT05845736

Last Updated: 2023-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

353 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2022-12-12

Brief Summary

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Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension. However, studies have shown that in aging adults, high blood pressure helps prevent against cognitive decline, and low blood pressure on antihypertensive drugs could accelerate it. This study aims at investigating if pharmacological treatment of hypertension in the very elderly is influenced by presence and severity of neurocognitive disorders. Our research hypothesis is that the drug management of hypertension in patients 80 years of age or older more is all the less aggressive as the neurocognitive disorders are advanced.

Detailed Description

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Conditions

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Neurocognitive Disorders Dementia Hypertension Aged, 80 and Over

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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control group

absence of neurocognitive disorder (ND), Mini-Mental State Examination (MMSE) from 27 to 30 inclusive

Antihypertensive Agents

Intervention Type DRUG

number of hypertensive drugs

mild neurocognitive disorder

MMSE from 21 to 26 inclusive

Antihypertensive Agents

Intervention Type DRUG

number of hypertensive drugs

moderate neurocognitive disorder

MMSE from 11 to 20 inclusive

Antihypertensive Agents

Intervention Type DRUG

number of hypertensive drugs

severe neurocognitive disorder

MMSE less than or equal to 10

Antihypertensive Agents

Intervention Type DRUG

number of hypertensive drugs

Interventions

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Antihypertensive Agents

number of hypertensive drugs

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* to be 80 years of age
* with history of hypertension and/or on hypertensive drug(s)

Exclusion Criteria

* legal protection measure.
Minimum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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Pr Athanase BENETOS

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Centre Hospitalier Régional Universitaire de Nancy

Nancy, , France

Site Status

Countries

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France

Other Identifiers

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2023PI017

Identifier Type: -

Identifier Source: org_study_id

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