Identification of Predictors for Early Cognitive Decline in Men
NCT ID: NCT03290040
Last Updated: 2023-11-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
564 participants
OBSERVATIONAL
2015-01-31
2022-12-31
Brief Summary
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Detailed Description
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Additionally, persons diagnosed with either MCI or AD will be included from the Memory Clinic at Herlev Hospital.
Researchers aim to identify factors earlier in life that affects or predict changes in cognitive function, specifically of cognitive decline in order to predict healthy vs unhealthy cognitive ageing, including progression to possible dementia. The objective is to be able to predict cognitive decline in ageing.
During the years of data collection, approximately 550 participants will be included and examined.
The examinations include:
* Cognitive test including Cambridge Neuropsychological test automated Battery (CANTAB);
* Sleep
* Life events
* Depression questionnaire
* Blood sample analysis including functional analyses of mitochondria and gene analyses such as genome scanning, SNP analysis
* ApoE ε-type
* Structural and functional changes in the brain measured with magnetic resonance (fMRI)
* Electroencephalography (EEG) recordings of electrical activity and visual attention
* PET-scan (Amyloid and FDG)
The results from these studies will hopefully point to new avenues for intervention in order to change the course of brain ageing
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Metropolit Cohort
Danish birth cohort of men born in 1953 in the Metropolitan area of Copenhagen. These test-persons are divided into two groups based on performance in cognitive tests at late midlife compared to young adulthood; Positive expected performance and negative expected performance and sampled from a birth cohort of 11.532 men.
No interventions assigned to this group
Herlev Hospital, Memory Clinic
Persons from the Memory Clinic at Herlev Hospital. These subjects are diagnosed with either MCI or AD.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Participants who have been informed about the project and who have signed the informed consent form
Exclusion Criteria
* Reduced ability to understand project information
* Reduced ability to complete the examinations
* Abuse of alcohol, psychedelic drugs or habit-forming drugs
* Certain neurological disorders
* Certain neurological, mental or psychiatric diagnoses
* Certain depressive diseases
* Former traumatic brain injury
* Contraindication for MR scanning
* Pathological MR result
* Persons that do not like to be informed about a possible pathological result
60 Years
MALE
No
Sponsors
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University of Copenhagen
OTHER
Herlev Hospital
OTHER
Rigshospitalet, Denmark
OTHER
Responsible Party
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Martin Lauritzen
Professor, Consulting
Principal Investigators
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Martin J Lauritzen, Prof
Role: PRINCIPAL_INVESTIGATOR
Dept. of Clinical Neurophysiology, Rigshospitalet - Glostrup
Martin J Lauritzen, Prof
Role: PRINCIPAL_INVESTIGATOR
Dept. of Clinical Neurophysiology, Rigshospitalet - Glostrup, Neuronal Signalling Lab, Center for Neuroscience, and Center for Healthy aging, University of Copenhagen
Locations
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Dept. of Clinical Neurophysiology, Department of Clinical Biochemistry and Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet - Glostrup
Glostrup Municipality, , Denmark
Countries
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Other Identifiers
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H-1-2014-032
Identifier Type: -
Identifier Source: org_study_id