Prognosis of Geriatric Patients 1 Year After Hospitalization for COVID-19

NCT ID: NCT05261061

Last Updated: 2022-06-30

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-07-31
• Study Completion Date: 2022-12-31

Brief Summary

Old patients hospitalized in Acute Geriatric Units are characterize by advanced age, frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy. Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors).

For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Detailed Description

Old patients hospitalized in Acute Geriatric Units are characterize by advanced age (average 85 years), frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy.These particular state leads to multiple decompensations and the reason for initial hospitalization is often only the "tip of the iceberg". Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors).

For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). This excess mortality is all the more surprising as these patients seem to have fewer comorbidities than those usually hospitalized in acute geriatric units.

Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Conditions

COVID-19

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Old patients hospitalized in acute geriatric unit

No interventions assigned to this group

Old patients hospitalized for other medical diagnosis in acute geriatric unit

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Age >=75 years
• Hospitalized for medical reason in acute geriatric unit
• Alive at hospital discharge

Exclusion Criteria

• Patients hospitalized for surgical reason
• Patients under legal protection
• Patient refusal

• Minimum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Hélène VALLET, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

AP-HP- Sorbonne université

Locations

Service de gériatrie, Hôpital Saint Antoine

Paris, , France

Countries

France

Central Contacts

Hélène VALLET, MD, PhD

Role: CONTACT

Helene.vallet@aphp.fr

+33149282042

Facility Contacts

Hélène VALLET, MD, PhD

Role: primary

Helene.vallet@aphp.fr

+33149282042

Other Identifiers

IDRCB 2021-A02684-37

Identifier Type: OTHER

Identifier Source: secondary_id

APHP211505

Identifier Type: -

Identifier Source: org_study_id