Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients

NCT ID: NCT05052450

Last Updated: 2021-09-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2000-01-01
• Study Completion Date: 2020-12-31

Brief Summary

Dementia; It is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension. The prognosis of this progressive and neurodegenerative disease after diagnosis may differ between individuals. In its broadest sense, the prognosis after a diagnosis of dementia; can be defined by shortening of life span, high level of cognitive and functional loss, decrease in quality of life and increased need for care. However, the prognosis of different types of dementia is highly variable. Because it is the most common type of dementia, studies are usually on Alzheimer's disease. It constitutes 50-75% of total dementia cases. Vascular dementia is the second most common cause of dementia and accounts for approximately 15% of dementia cases. Dementia with Lewy bodies constitutes 10-20% of the total dementia patients and ranks second among degenerative dementia types. Frontotemporal dementia, which mimics psychiatric disorders and has prominent behavioural problems, and Parkinson's disease-associated dementia, which is characterized by cognitive impairment that can be added to the existing picture in Parkinson's patients, are also counted among other types of dementia. Prognosis-related data on dementia types other than Alzheimer's disease are limited in the literature. Determining the prognosis is important to support patients, anticipate long-term health problems, plan physician and healthcare provision, and support patients with dementia.In view of the lack of sufficient data on dementia types other than Alzheimer's disease, it is aimed to contribute to the literature on this subject and to determine the factors that may affect prognosis, morbidity and mortality in patients belonging to all dementia types.

Conditions

Dementia; Dementia, Vascular; Dementia With Lewy Bodies; Dementia of Alzheimer Type; Dementia Frontal; Dementia, Mixed

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Dementia with Alzheimer

Patients previously diagnosed with Alzheimer disease would be included

Observational

Intervention Type: OTHER

Patients data were collected throughout the following time

Dementia with Lewy Body Dementia

Patients previously diagnosed with Lewy Body Dementia would be included

Observational

Intervention Type: OTHER

Patients data were collected throughout the following time

Dementia with Fronto-Temporal Dementia

Patients previously diagnosed with Fronto-Temporal Dementia would be included

Observational

Intervention Type: OTHER

Patients data were collected throughout the following time

Dementia with Vascular Disease

Patients previously diagnosed with Dementia with Vascular Disease would be included

Observational

Intervention Type: OTHER

Patients data were collected throughout the following time

Dementia with Parkinson Disease

Patients previously diagnosed with Dementia with Parkinson Disease would be included

Observational

Intervention Type: OTHER

Patients data were collected throughout the following time

Interventions

Observational

Patients data were collected throughout the following time

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

Having applied to the Gulhane Training and Research Hospital Geriatrics Polyclinic Being diagnosed with Alzheimer or Lewy Body Dementia or Vascular Dementia or Fronto-Temporal Dementia or Parkinson Disease Dementia Being at the age of 60 years or older

Exclusion Criteria

Being under the age of 60 Patients with insufficient recorded data and follow-up for the study Patients who either have diagnosis or follow-up in another center. Patients who have severe dementia that prevents applying for outpatient clinic

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Gulhane Training and Research Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

Neslihan Kayahan

Medical Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Naharci MI, Kayahan Satis N, Ozsurekci C, Tasci I. Assessment of clinical features and coexisting geriatric syndromes in newly diagnosed dementia with Lewy bodies: a retrospective study in a tertiary geriatrics setting in Turkey. Eur Geriatr Med. 2023 Feb;14(1):19-27. doi: 10.1007/s41999-022-00727-0. Epub 2022 Dec 13.

Reference Type: DERIVED

PMID: 36512254 (View on PubMed)

Other Identifiers

2021/290

Identifier Type: -

Identifier Source: org_study_id