Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus
NCT ID: NCT01809977
Last Updated: 2013-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
22 participants
INTERVENTIONAL
2012-07-31
2012-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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total removal
patients underwent Corneal collagen cross-linking procedure with totally corneal epithelium removing. Total removal was performed by mechanical debridement of the corneal epithelium over the central 9 mm.
collagen cross-linking procedure (total removal)
patients underwent Corneal collagen cross-linking procedure with totally corneal epithelium removing. Total removal was performed by mechanical debridement of the corneal epithelium over the central 9 mm.
partial removal
patients underwent Corneal collagen cross-linking procedure with partially corneal epithelium removing. Partial removal was performed by removing a 3-mm width ring and leaving the central 3 mm of the cornea intact.
collagen cross-linking procedure (partial removal)
patients underwent Corneal collagen cross-linking procedure with partially corneal epithelium removing. Partial removal was performed by removing a 3-mm width ring and leaving the central 3 mm of the cornea intact.
Interventions
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collagen cross-linking procedure (total removal)
patients underwent Corneal collagen cross-linking procedure with totally corneal epithelium removing. Total removal was performed by mechanical debridement of the corneal epithelium over the central 9 mm.
collagen cross-linking procedure (partial removal)
patients underwent Corneal collagen cross-linking procedure with partially corneal epithelium removing. Partial removal was performed by removing a 3-mm width ring and leaving the central 3 mm of the cornea intact.
Eligibility Criteria
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Inclusion Criteria
* axial topography consistent with keratoconus
* minimum corneal thickness more than 400 µm and a progression of keratoconus in past 12 months
Exclusion Criteria
* subjects with current ocular infection
* severe preoperative corneal haze or scar
* severe ocular surface disease
* autoimmune diseases
* pregnant women
16 Years
40 Years
ALL
Yes
Sponsors
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Isfahan University of Medical Sciences
OTHER
Responsible Party
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Hamidreza Shemshaki
MD, Research Assistant
Principal Investigators
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Behrooz Rahimi, MD
Role: PRINCIPAL_INVESTIGATOR
MD, Departement of ophtalmology, Isfahan University of Medical Sciences, Isfahan, Iran
Locations
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Feyz university hospital
Isfahan, Isfahan, Iran
Countries
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References
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Razmjoo H, Rahimi B, Kharraji M, Koosha N, Peyman A. Corneal haze and visual outcome after collagen crosslinking for keratoconus: A comparison between total epithelium off and partial epithelial removal methods. Adv Biomed Res. 2014 Nov 29;3:221. doi: 10.4103/2277-9175.145677. eCollection 2014.
Other Identifiers
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ASD-1213-39
Identifier Type: -
Identifier Source: org_study_id
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