China Action on Spine and Hip Status

NCT ID: NCT01758770

Last Updated: 2018-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3457 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2017-07-26

Brief Summary

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1. To determine the prevalences of osteoporotic fracture in elderly Chinese population.
2. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement.
3. To investigate the difference in the prevalences of osteoporosis between cities and urban-rural area in China.
4. To investigate the association of body composition with osteoporosis
5. To investigate the prevalence of liver steatosis in China
6. To investigate the application of QCT fat measurement

Detailed Description

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Osteoporosis and osteoarthritis (OA) both are very common in elderly population,it is particular important for China with a huge aging population in the coming years.Bone mineral density measured by quantitative computed tomography (QCT) or dual energy X-ray absorptiometry (DXA) is the surrogate for bone health status and diagnosis of osteoporosis and OA. In this study we utilize the large-scale population based epidemiology study (PURE) population,spine and hip QCT and/or DXA will be obtained for the subject to investigate the prevalence of osteoporosis and osteoarthritis in elderly Chinese population. We also study the relation between bone mineral density with osteoporotic fracture and OA More than 3000 subjects selected from the PURE study participants in Beijing and other centers in China will be recruited to this study. More precisely, the subjects are consisted of the females over 55 years and males over 60 years old, along with the 20% randomly selected PURE participants for blood sampling.

Beijing ji shui tan hospital will be the coordinate center for the whole study, Beijing shi jing shan hospital, Beijing shun yi traditional medicine hospital and Taiyuan central hospital of shanxi will participate, other centers may be added late.

Bone mineral density of spine and hip will be measured with QCT and/or DXA. Quantitative computed tomography QCT pro (Mindways software, inc. USA) will be used for all QCT measurement, the CT scanner will be the clinical CT scanner of the local participated center.

Quality control and monitoring will be conducted by Beijing ji shui tan hospital, as well as the centralised image interpretation.

Therefore, this study is designed to provide the current and reliable prevalence of osteoporotic fracture, osteoporosis, OA in elderly Chinese population using QCT and/or DXA. The performance of QCT and DXA in the diagnosis of osteoporosis , as well as the association of body composition with osteoporosis will be assessed.

Conditions

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Osteoporosis Liver Steatosis Metabolic Syndrome Obesity

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Participants of the PURE study in China (PURE China study)
2. be willing to and be able to join in the study and signed Informed consent

Exclusion Criteria

1. Pregnant
2. Spine and both hip implants
Minimum Eligible Age

29 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fu Wai Hospital, Beijing, China

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role collaborator

Beijing Shi Jing Shan hospital,Beijing, China

UNKNOWN

Sponsor Role collaborator

Tai yuan central hospital,taiyuan, shanxi

UNKNOWN

Sponsor Role collaborator

Cheng Du Da Yi hospital,Cheng du, Sichuan

UNKNOWN

Sponsor Role collaborator

Shen Yang 4th hospital,shen yang, liaoning

UNKNOWN

Sponsor Role collaborator

Second hospital of sichuan university,Cheng du, Sichuan

UNKNOWN

Sponsor Role collaborator

Chang Zhou Wu Jin Traditional Chinese Medicine hospital

UNKNOWN

Sponsor Role collaborator

Red cross hospital of Shaanxi

UNKNOWN

Sponsor Role collaborator

No 1 TCM hospital of Jiangsu

UNKNOWN

Sponsor Role collaborator

No 2 TCM hospital of Jiangsu

UNKNOWN

Sponsor Role collaborator

Chengdu Second people's hospital

UNKNOWN

Sponsor Role collaborator

Affiliate hospital of jiangxi Traditional Chinese Medicine university

UNKNOWN

Sponsor Role collaborator

Beijing Jishuitan Hospital

OTHER

Sponsor Role lead

Responsible Party

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xiaoguang Cheng

Chairman, department of radiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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xiaoguang cheng, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing ji shui tan hospital

Locations

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Beijing ji shui tan hospitla

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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jst2012cash

Identifier Type: -

Identifier Source: org_study_id

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