Associations Analysis Between Lifestyle and Osteoporosis

NCT ID: NCT02451397

Last Updated: 2021-01-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 3100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-01-31
• Study Completion Date: 2020-12-31

Brief Summary

A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods.

Detailed Description

A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods. More than 3000 participants were recruited in communities in Shanghai. Data involved in demographic information, lifestyle, dietary habits, medical history and clinical biomarkers were collected. Every participants were measured bone mineral density (BMD g/cm2) at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria. A standard statistical analysis including univariate and multiple variables regression analysis to explore the risk or preventive factors involved in Chinese lifestyle associated with osteoporosis.

Conditions

Osteoporosis of Disuse With Current Pathological Fracture

Study Design

• Observational Model Type: ECOLOGIC_OR_COMMUNITY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Dr.Tang's research group

Chinese lifestyle associated with osteoporosis

Intervention Type: OTHER

This is a cross-sectional study, and we do not assign specific interventions to the subjects of the study.

Interventions

This is a cross-sectional study, and we do not assign specific interventions to the subjects of the study.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Participants aged 30-90 years were recruited from rural and urban communities in Shanghai.

Exclusion Criteria

1. serious residual effects of cerebral vascular disease;

2. serious chronic renal disease (Glomerular filtration rate - GFR < 30 mL/min/1.73m2);

3. serious chronic liver disease or alcoholism;

4. significant chronic lung disease;

5. corticosteroid therapy at pharmacologic levels;

6. evidence of other metabolic or inherited bone disease, such as hyper- or hypoparathyroidism, Paget disease, osteomalacia, or osteogenesis imperfecta;

7. recent (within the past year) major gastrointestinal disease, such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or significant chronic diarrhea;

8. Cushing syndrome;

9. hyperthyroidism; and

10. any neurologic or musculoskeletal condition that would be a non-genetic cause of low bone mass.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Huashan Hospital

OTHER

Sponsor Role: collaborator

Shanghai Tongji Hospital, Tongji University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Zihui Tang

M.D and Ph.D

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Zihui Tang, M.D and Ph.D

Role: PRINCIPAL_INVESTIGATOR

Huashan Hospital

Locations

Huasha Hospital

Shanghai, Shanghai Municipality, China

Huashan Hospital

Shanghai, Shanghai Municipality, China

Countries

China

References

Tang ZH, Zeng F, Li Z, Zhou L. Association and predictive value analysis for resting heart rate and diabetes mellitus on cardiovascular autonomic neuropathy in general population. J Diabetes Res. 2014;2014:215473. doi: 10.1155/2014/215473. Epub 2014 Mar 18.

Reference Type: BACKGROUND

PMID: 24772443 (View on PubMed)

Tang ZH, Xiao P, Lei SF, Deng FY, Zhao LJ, Deng HY, Tan LJ, Shen H, Xiong DH, Recker RR, Deng HW. A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. J Clin Endocrinol Metab. 2007 Jul;92(7):2751-7. doi: 10.1210/jc.2006-2607. Epub 2007 May 1.

Reference Type: BACKGROUND

PMID: 17473065 (View on PubMed)

Tang ZH, Wang L, Zeng F, Li Z, Yu X, Zhang K, Zhou L. Bayesian estimation of cardiovascular autonomic neuropathy diagnostic test based on short-term heart rate variability without a gold standard. BMJ Open. 2014 Oct 6;4(9):e005096. doi: 10.1136/bmjopen-2014-005096.

Reference Type: BACKGROUND

PMID: 25287103 (View on PubMed)

Li X, Lei T, Tang Z, Dong J. Analyzing the association between fish consumption and osteoporosis in a sample of Chinese men. J Health Popul Nutr. 2017 Apr 19;36(1):13. doi: 10.1186/s41043-017-0088-y.

Reference Type: DERIVED

PMID: 28424092 (View on PubMed)

Yu Q, Liu ZH, Lei T, Tang Z. Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men. J Health Popul Nutr. 2016 Aug 5;35(1):24. doi: 10.1186/s41043-016-0060-2.

Reference Type: DERIVED

PMID: 27495290 (View on PubMed)

Liu N, Zeng F, Zhang K, Tang Z. A community-based cross-sectional study for relationship of frequency of vegetables intake and osteoporosis in a Chinese postmenopausal women sample. BMC Womens Health. 2016 Jun 3;16:28. doi: 10.1186/s12905-016-0307-5.

Reference Type: DERIVED

PMID: 27259804 (View on PubMed)

Yu CX, Zhang XZ, Zhang K, Tang Z. A cross-sectional study for estimation of associations between education level and osteoporosis in a Chinese men sample. BMC Musculoskelet Disord. 2015 Dec 9;16:382. doi: 10.1186/s12891-015-0839-0.

Reference Type: DERIVED

PMID: 26646811 (View on PubMed)

Liu N, Chen J, Zhang K, Tang Z. A community-based study of the relationship between coronary artery disease and osteoporosis in Chinese postmenopausal women. Coron Artery Dis. 2016 Jan;27(1):59-64. doi: 10.1097/MCA.0000000000000306.

Reference Type: DERIVED

PMID: 26398152 (View on PubMed)

Other Identifiers

OPLA_Dr.Tang

Identifier Type: -

Identifier Source: org_study_id